Detailed information of TA system TA182471

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2121663..2121861
• Replicon: chromosome
• Accession: NZ_CP065355
• Organism: Staphylococcus aureus strain JW31330_O1_dhc

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: -
• Locus tag: I5046_RS10375
• Protein ID: WP_078064523.1
• Coordinates: 2121757..2121861 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2121663..2121701 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I5046_RS10355 (I5046_10355)	2117774..2118439	-	666	WP_001024086.1	SDR family oxidoreductase	-
I5046_RS10360 (I5046_10360)	2118591..2118911	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I5046_RS10365 (I5046_10365)	2118913..2119893	+	981	WP_000019746.1	CDF family zinc efflux transporter CzrB	-
I5046_RS10370 (I5046_10370)	2120159..2121250	+	1092	WP_000495687.1	hypothetical protein	-
I5046_RS13420	2121643..2121717	+	75	Protein_2011	hypothetical protein	-
-	2121663..2121701	+	39	-	-	Antitoxin
I5046_RS10375 (I5046_10375)	2121757..2121861	-	105	WP_078064523.1	hypothetical protein	Toxin
I5046_RS10380 (I5046_10380)	2122022..2122505	-	484	Protein_2013	recombinase family protein	-
I5046_RS10385 (I5046_10385)	2122548..2123684	-	1137	WP_000115566.1	SAP domain-containing protein	-
I5046_RS10390 (I5046_10390)	2123973..2124065	+	93	WP_031844941.1	hypothetical protein	-
I5046_RS10395 (I5046_10395)	2124768..2125625	-	858	WP_029753951.1	HAD family hydrolase	-
I5046_RS10400 (I5046_10400)	2125693..2126475	-	783	WP_000908184.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T182471 WP_078064523.1 NZ_CP065355:c2121861-2121757 [Staphylococcus aureus]
MLILERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T182471 NZ_CP086467:c4890090-4889806 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT182471 NZ_CP065355:2121663-2121701 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Antitoxin