Detailed information of TA system TA182295

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2822908..2823487
• Replicon: chromosome
• Accession: NZ_CP065194
• Organism: Staphylococcus aureus strain GDC6P096P

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: I3K80_RS13790
• Protein ID: WP_001025401.1
• Coordinates: 2822908..2823153 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2823122..2823487 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I3K80_RS13745	2818925..2819539	+	615	WP_000191466.1	hypothetical protein	-
I3K80_RS13750	2819536..2819682	-	147	WP_074370993.1	hypothetical protein	-
I3K80_RS13755	2819913..2820497	-	585	WP_031918390.1	hypothetical protein	-
I3K80_RS13760	2820515..2820976	-	462	WP_000525004.1	hypothetical protein	-
I3K80_RS13765	2820989..2821303	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
I3K80_RS13770	2821455..2821691	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
I3K80_RS13775	2821705..2822481	+	777	WP_001148544.1	Rha family transcriptional regulator	-
I3K80_RS13780	2822510..2822653	+	144	WP_000939498.1	hypothetical protein	-
I3K80_RS13785	2822643..2822852	-	210	WP_000642492.1	hypothetical protein	-
I3K80_RS13790	2822908..2823153	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
I3K80_RS13795	2823122..2823487	-	366	WP_016170627.1	hypothetical protein	Antitoxin
I3K80_RS13800	2823542..2823757	+	216	WP_001097552.1	hypothetical protein	-
I3K80_RS13805	2823782..2824045	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
I3K80_RS13810	2824058..2824228	+	171	WP_031838382.1	DUF1270 domain-containing protein	-
I3K80_RS13815	2824233..2824547	+	315	WP_031838381.1	hypothetical protein	-
I3K80_RS13820	2824612..2824914	+	303	WP_031838380.1	DUF2482 family protein	-
I3K80_RS13825	2824919..2825179	+	261	WP_000291481.1	DUF1108 family protein	-
I3K80_RS13830	2825192..2825728	+	537	WP_000999048.1	host-nuclease inhibitor Gam family protein	-
I3K80_RS13835	2825729..2826508	+	780	WP_000137071.1	ATP-binding protein	-
I3K80_RS13840	2826538..2827092	+	555	WP_000704713.1	single-stranded DNA-binding protein	-
I3K80_RS13845	2827105..2827776	+	672	WP_031838379.1	phi PV83 orf 19-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2817594..2839116	21522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T182295 WP_001025401.1 NZ_CP065194:2822908-2823153 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T182295 NZ_CP086391:2351546-2351653 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT182295 NZ_CP065194:c2823487-2823122 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin