Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4033930..4034549 Replicon chromosome
Accession NZ_CP065167
Organism Klebsiella pneumoniae strain KPN114

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I3U24_RS19840 Protein ID WP_002892050.1
Coordinates 4034331..4034549 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I3U24_RS19835 Protein ID WP_002892066.1
Coordinates 4033930..4034304 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U24_RS19825 4029082..4030275 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I3U24_RS19830 4030298..4033444 + 3147 WP_004147373.1 multidrug efflux RND transporter permease subunit -
I3U24_RS19835 4033930..4034304 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I3U24_RS19840 4034331..4034549 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I3U24_RS19845 4034708..4035274 + 567 WP_002892030.1 maltose O-acetyltransferase -
I3U24_RS19850 4035246..4035386 - 141 WP_004147370.1 hypothetical protein -
I3U24_RS19855 4035407..4035877 + 471 WP_002892026.1 YlaC family protein -
I3U24_RS19860 4035852..4037303 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I3U24_RS19865 4037404..4038102 + 699 WP_040220001.1 GNAT family N-acetyltransferase -
I3U24_RS19870 4038099..4038239 - 141 WP_040219999.1 type B 50S ribosomal protein L36 -
I3U24_RS19875 4038239..4038502 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T182217 WP_002892050.1 NZ_CP065167:4034331-4034549 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T182217 NZ_CP086342:c2118790-2118683 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT182217 WP_002892066.1 NZ_CP065167:4033930-4034304 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT182217 NZ_CP086342:2118838-2118904 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References