182096

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4557245..4558059 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag I2T83_RS21900 Protein ID WP_001054376.1
Coordinates 4557245..4557502 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag I2T83_RS21905 Protein ID WP_001309181.1
Coordinates 4557514..4558059 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS21880 4552533..4553639 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
I2T83_RS21885 4553704..4554684 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
I2T83_RS21890 4555267..4556507 - 1241 Protein_4287 DNA helicase -
I2T83_RS21895 4556623..4556868 + 246 Protein_4288 GNAT family N-acetyltransferase -
I2T83_RS21900 4557245..4557502 + 258 WP_001054376.1 hypothetical protein Toxin
I2T83_RS21905 4557514..4558059 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
I2T83_RS21910 4558115..4558861 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
I2T83_RS21915 4559030..4559248 + 219 Protein_4292 hypothetical protein -
I2T83_RS21920 4559286..4559402 + 117 Protein_4293 VOC family protein -
I2T83_RS21925 4559647..4560768 + 1122 WP_000010829.1 M42 family metallopeptidase -
I2T83_RS21930 4560765..4561043 + 279 WP_000722973.1 PTS sugar transporter subunit IIB -
I2T83_RS21935 4561055..4562368 + 1314 WP_000460843.1 galactitol-specific PTS transporter subunit IIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T182096 WP_001054376.1 NZ_CP065136:4557245-4557502 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T182096 NZ_CP086305:c2247058-2246147 [Burkholderia ambifaria]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
TGCAGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGTGCCAGCTCGACACGCTCGGCGCGTCGCGA
CGCGTGCTTGCGTGGGATGCGCCCGGCTACGGCGTGTCGACCCCCGTGCACGGCGCGTCGCCTACCGCCGCCGATTACGC
GGCGTCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCG
CGGGTGGCTTGTGCCGCCTGATGCCCGCGAGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCAGGGCG
CCCGCCGAAACGCGCGACACGCGCCGCGACGCGCGCCTCGCGCTGCTCGAGGAACTCGGTCCGGCCGGGCTTGCCGAGCA
GCGCAGCGGCAACATGCTGTCGGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGC
CGGCCGGCTATGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGCACG
GCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAATT
GCAGGTGATTCCGCAGGCCGGTCATGCCGGCTATGTGGAAGCGCCGGCCGTCTATTCGTCGCTCATCGACACATTTTGCC
GTCAGTGCGACACGCAGCGAGGCATGGCATGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT182096 WP_001309181.1 NZ_CP065136:4557514-4558059 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT182096 NZ_CP086305:c2246150-2245293 [Burkholderia ambifaria]
ATGAGCGAACCGCTGCAACAACCCGAATCCGAGAGCACCAAGGCCGACGCCGGCTACGTGGTGCCGGGCCTCGAACGCGG
CCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCGGACAAGGATCGCAACTACAAG
CTGGGCATCGCGGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAATTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACTGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGTGCCAGTCGCCGGTGTTCAGCGCGATTCGCGTGAACGTCGGCACGCGGTTGCCCGCGCATGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGTGCGCTGTATCCGGAAGGCACGCTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGTTGCGCGGCTACGGCATCAGCAATTCGTCGTTCG
AGCGCGGTATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGAGGCGCTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References