Detailed information of TA system TA181845

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3195451..3195709
• Replicon: chromosome
• Accession: NZ_CP064855
• Organism: Erwinia amylovora strain Ea1/79Sm

Toxin (Protein)

• Gene name: hok
• Uniprot ID: D4I1C1
• Locus tag: IYV53_RS14610
• Protein ID: WP_004160031.1
• Coordinates: 3195451..3195609 (-)
• Length: 53 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	3195663..3195709 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IYV53_RS14595	3190756..3192447	-	1692	WP_004160025.1	chloride channel protein	-
IYV53_RS14600	3192860..3193840	+	981	WP_013035818.1	TerC family protein	-
IYV53_RS14605	3194075..3195307	+	1233	WP_004160030.1	serine/threonine transporter SstT	-
IYV53_RS14610	3195451..3195609	-	159	WP_004160031.1	type I toxin-antitoxin system Hok family toxin	Toxin
-	3195663..3195709	+	47	-	-	Antitoxin
IYV53_RS14615	3196420..3197094	+	675	WP_004160034.1	DedA family protein	-
IYV53_RS14620	3197091..3197483	+	393	WP_004160035.1	EnvZ/OmpR regulon moderator MzrA	-
IYV53_RS14625	3197651..3198022	+	372	WP_004160036.1	DUF1090 domain-containing protein	-
IYV53_RS14630	3198065..3198370	+	306	WP_004160037.1	DUF883 family protein	-
IYV53_RS14635	3198372..3198764	+	393	WP_004160038.1	phage holin family protein	-
IYV53_RS14640	3198764..3199045	+	282	WP_004160039.1	YqjK-like family protein	-
IYV53_RS14645	3199255..3199647	+	393	WP_004160048.1	DoxX family protein	-
IYV53_RS14650	3200120..3200263	+	144	WP_004160049.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (8-48)

Sequences

Toxin

Protein

• Length: 53 a.a.
• Molecular weight: 6038.32 Da
• Isoelectric Point: 8.4901

>T181845 WP_004160031.1 NZ_CP064855:c3195609-3195451 [Erwinia amylovora]
MKLPANCLIWCVLIVCVTLLIFTYLTRKSLCEIRYKDGYREVAAFMAYESGK

Nucleotide

• Length: 159 bp

>T181845 NZ_CP086185:c180284-180033 [Xanthomonas oryzae]
ATGCTACGGCTGCGTGAATTCCTGAGGCCGAAGAATCCCGATGCCGCGAGGCGGGCCGGCGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGTCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGCGGCTATGTGGCTCGGTACCGCTTCGATGGGGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin

Nucleotide

• Length: 47 bp

>AT181845 NZ_CP064855:3195663-3195709 [Erwinia amylovora]
GCATGCAGATGGCCTCGTGGATTAATGAAAATTAACTACGGGGCTTT

Structures

Toxin

• AlphaFold DB: A0A831A7I1

Antitoxin