Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 973795..974421 Replicon chromosome
Accession NZ_CP064829
Organism Morganella morganii subsp. morganii strain 621164

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IZ188_RS04460 Protein ID WP_024474604.1
Coordinates 973795..973998 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IZ188_RS04465 Protein ID WP_004236473.1
Coordinates 974062..974421 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ188_RS04440 (IZ188_04440) 970351..970689 + 339 WP_004236467.1 P-II family nitrogen regulator -
IZ188_RS04445 (IZ188_04445) 970709..971998 + 1290 WP_036422539.1 ammonium transporter AmtB -
IZ188_RS04450 (IZ188_04450) 972059..972922 - 864 WP_004240378.1 acyl-CoA thioesterase II -
IZ188_RS04460 (IZ188_04460) 973795..973998 - 204 WP_024474604.1 HHA domain-containing protein Toxin
IZ188_RS04465 (IZ188_04465) 974062..974421 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IZ188_RS04470 (IZ188_04470) 974984..978160 - 3177 WP_015422956.1 efflux RND transporter permease subunit -
IZ188_RS04475 (IZ188_04475) 978175..979371 - 1197 WP_015422955.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T181799 WP_024474604.1 NZ_CP064829:c973998-973795 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T181799 NZ_CP086174:3241777-3242043 [Streptomyces fungicidicus]
GTGAGTAGCGGCTACCGCACCGTCTTCCGGCCGGAGGCTCAGGCGGAGCTTCGCAAGATTCCCCGGGACATGGCCCTGAG
GATCCTGGTCAAACTGACGGAACTGGAAACGGACCCGCTCGGCTTCCGCACCACGGCGCTCGTCTCCCGGCCCGACCGGC
GCCGGCTCCGTGTCGGCGACTACCGCGTCATCTACACGATCGACAACGGCGAGTTGACGGTCTGGGTCGTTCATGTCGGA
CACCGCTCCACGGTATACGACACCTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT181799 WP_004236473.1 NZ_CP064829:c974421-974062 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT181799 NZ_CP086174:3241518-3241784 [Streptomyces fungicidicus]
ATGACCGAGATGCCCATAGAGTCCATTCGTGACGTGCGCGCCCACCTGGCCGAGGTGGTCGAACGGGCGGACCGGGACGA
CACGCCCACGGTCATCACCCGGCGAGGCAAGCAGGTGGCCGCAGTCGTGTCGATGGAGGTCCTTCGCAAGTACCAGGAAT
GGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCGAACCCGGCAGCCGGTATCCCGATCGAGGACGTCATG
CGGGAGACGCTGGAGCGCGGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References