Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 887121..887747 Replicon chromosome
Accession NZ_CP064828
Organism Morganella morganii subsp. morganii strain ZJC25

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IZ183_RS04070 Protein ID WP_024474604.1
Coordinates 887121..887324 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J7U1S9
Locus tag IZ183_RS04075 Protein ID WP_004236473.1
Coordinates 887388..887747 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ183_RS04050 (IZ183_04050) 883677..884015 + 339 WP_004236467.1 P-II family nitrogen regulator -
IZ183_RS04055 (IZ183_04055) 884035..885324 + 1290 WP_036422539.1 ammonium transporter AmtB -
IZ183_RS04060 (IZ183_04060) 885385..886248 - 864 WP_062771844.1 acyl-CoA thioesterase II -
IZ183_RS04070 (IZ183_04070) 887121..887324 - 204 WP_024474604.1 HHA domain-containing protein Toxin
IZ183_RS04075 (IZ183_04075) 887388..887747 - 360 WP_004236473.1 Hha toxicity modulator TomB Antitoxin
IZ183_RS04080 (IZ183_04080) 888001..889209 + 1209 WP_001339197.1 IS4-like element ISVsa5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 888001..889209 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T181794 WP_024474604.1 NZ_CP064828:c887324-887121 [Morganella morganii subsp. morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T181794 NZ_CP086148:165536-165793 [Clostridium estertheticum]
ATGAATAAGATTTTTTCAGAGGTATCATGGGAGCATTATGTATATTGGCAGTCAGAGGATAAAAAAATATTAAGAAAAAT
TAATGAACTTATAAAAGACATTGAAAGAAACGGAAATGAAGGTCTAGGAAAGCCAGAAGCATTAAAGCATGAGTTGGTAG
GTTATTGGAGTCGAAGAATAACAGATGTTCATAGACTTATATATAGTATTGATGATGAAAATATCTATGTTGCAAGCTGC
AAAGGACATTATCATTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13826.54 Da        Isoelectric Point: 4.2870

>AT181794 WP_004236473.1 NZ_CP064828:c887747-887388 [Morganella morganii subsp. morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVAWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT181794 NZ_CP086148:165289-165543 [Clostridium estertheticum]
ATGATCGCTATAGGTTACTCGAACGCAAGACAAAATTTTAAAAATTATTGTGACAAAGCTACAAAAGATTTTGAAACCAT
TATTATTACTCGAGAGCGTGGTGACAATGTGGTTATGTTATCTGAATCGGCATATAATAACCTTATGGAAAATTTGTACG
TTAGAAGTGATCCCACCTATTATAATGAATTGCTGAAATCTATTGACCAATTAAAAATGGGAAAGGGAATTAGAAAGGAA
CTTCTTGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB J7U1S9

References