Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 3655643..3656317 Replicon chromosome
Accession NZ_CP064826
Organism Morganella morganii subsp. morganii strain ZJD581

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IZ187_RS17335 Protein ID WP_143970176.1
Coordinates 3655643..3655966 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IZ187_RS17340 Protein ID WP_214211141.1
Coordinates 3656012..3656317 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IZ187_RS17315 (IZ187_17325) 3651071..3652333 - 1263 WP_205515190.1 multifunctional transcriptional regulator/nicotinamide-nucleotide adenylyltransferase/ribosylnicotinamide kinase NadR -
IZ187_RS17320 (IZ187_17330) 3652346..3653734 - 1389 WP_015422438.1 DNA repair protein RadA -
IZ187_RS17325 (IZ187_17335) 3653760..3654737 - 978 WP_112548193.1 phosphoserine phosphatase -
IZ187_RS17330 (IZ187_17340) 3654839..3655498 + 660 WP_143970177.1 YtjB family periplasmic protein -
IZ187_RS17335 (IZ187_17345) 3655643..3655966 + 324 WP_143970176.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IZ187_RS17340 (IZ187_17350) 3656012..3656317 + 306 WP_214211141.1 NadS family protein Antitoxin
IZ187_RS17345 (IZ187_17355) 3656369..3656752 - 384 WP_004237097.1 fluoride efflux transporter CrcB -
IZ187_RS17350 (IZ187_17360) 3656793..3657875 - 1083 WP_072872017.1 FUSC family protein -
IZ187_RS17355 (IZ187_17365) 3657888..3659054 - 1167 WP_214181951.1 NAD-binding protein -
IZ187_RS17360 (IZ187_17370) 3659067..3660059 - 993 WP_024475035.1 urea transporter -
IZ187_RS17365 (IZ187_17375) 3660153..3661118 - 966 WP_036409388.1 urease accessory protein UreD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(9-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-87)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12658.48 Da        Isoelectric Point: 9.8617

>T181791 WP_143970176.1 NZ_CP064826:3655643-3655966 [Morganella morganii subsp. morganii]
MDYLEFIETKIFSHTRKEMMTDDEFREFQSYLLENYERGNTISQTGGCKKIRWQRRGTGKQGGLRVIYHALPAHGRLYLL
LIYPKNVKDDLSSQERTVLRSLSQKLN

Download         Length: 324 bp

>T181791 NZ_CP086138:c87186-86779 [Bradyrhizobium barranii subsp. barranii]
ATGTATCTCATTGATACCAACGTCGTTTCCGAGGCTCGGCGCGGCTCTCCGCAGGCAACCGGCTGGCTGCGCTCGGTGGA
TCCGGCCAGCGTCTACCTGAGCACCCTCACCCTCGGCGAGATCATGCGCGGCATCGCGCTGAAGCAGAAGTCGGACCCGA
AGGTGGCCGGCCACCTTGCCGAATGGTTGCGCAAGTTGCGCCACGACCACGCCAACCGCATCCTGGCGGTGACCGACCAG
ATCTCCGTCGAGTGGGGTCGCATCGCCGCGATCCGGCCGTGTGGCGATATCGACGGGCTGATCGCCGCAACCGCGATCGT
CCACGACCTCATCCTCGTCACTCGCAATGTGGGGGATTTCGACGATACGGGCGCAACGGTGATCAATCCCTGGGAGGCGT
CGACATGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11492.46 Da        Isoelectric Point: 9.8337

>AT181791 WP_214211141.1 NZ_CP064826:3656012-3656317 [Morganella morganii subsp. morganii]
MDKTLFENLVSSMEEMVAIEKGHVVPAQENRHRHPIPDVKAIRKHAGLKQTEFADAIGSSVDLVRSWEQHRRIPSGIALK
MLYLIEKQPALLCTLRSIPLR

Download         Length: 306 bp

>AT181791 NZ_CP086138:c87440-87186 [Bradyrhizobium barranii subsp. barranii]
ATGGAATGGCCGCTGCAGGACGCCAAGAACCAGTTTTCCAAGGTGGTGCAGAAGGCCCGCCTGGAAGGCCCGCAGGTCGT
CACCCTGCGCGGGATGCGCGCCGCGGTGGTGCTGTCGGCCGCCGATTACGATGCGCTGCGCTCCGGGCGGCCGACCTTGG
TCGACGACTTGCTGGCCGGGCCAAGCTGGGATGACGAACTGGCCGAAGAAGCGATGCGGCGCATCAAGACCCCCAGCCGC
GACGCGGCCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References