Detailed information of TA system TA181705

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2277833..2278362
• Replicon: chromosome
• Accession: NZ_CP064772
• Organism: Staphylococcus aureus strain TCH32767

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: IXH55_RS11110
• Protein ID: WP_000621175.1
• Coordinates: 2278000..2278362 (+)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: IXH55_RS11105
• Protein ID: WP_000948331.1
• Coordinates: 2277833..2278003 (+)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXH55_RS11075 (IXH55_11015)	2272870..2273430	+	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-
IXH55_RS11080 (IXH55_11020)	2273638..2274117	+	480	WP_001287087.1	hypothetical protein	-
IXH55_RS11085 (IXH55_11025)	2274110..2275693	+	1584	WP_001294626.1	PH domain-containing protein	-
IXH55_RS11090 (IXH55_11030)	2275680..2276171	+	492	WP_001205912.1	PH domain-containing protein	-
IXH55_RS11095 (IXH55_11035)	2276175..2276534	+	360	WP_000581197.1	holo-ACP synthase	-
IXH55_RS11100 (IXH55_11040)	2276600..2277748	+	1149	WP_001281154.1	alanine racemase	-
IXH55_RS11105 (IXH55_11045)	2277833..2278003	+	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
IXH55_RS11110 (IXH55_11050)	2278000..2278362	+	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
IXH55_RS11115 (IXH55_11055)	2278712..2279713	+	1002	WP_000390827.1	PP2C family protein-serine/threonine phosphatase	-
IXH55_RS11120 (IXH55_11060)	2279832..2280158	+	327	WP_001052491.1	anti-sigma factor antagonist	-
IXH55_RS11125 (IXH55_11065)	2280160..2280639	+	480	WP_001190829.1	anti-sigma B factor RsbW	-
IXH55_RS11130 (IXH55_11070)	2280614..2281384	+	771	WP_001041111.1	RNA polymerase sigma factor SigB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T181705 WP_000621175.1 NZ_CP064772:2278000-2278362 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T181705 NZ_CP086104:2139235-2140572 [Ralstonia sp. RS650]
ATGGCGCATCCCGAACTGCATCTGTGGATGAACGGCGAGCATGTCGGCATCTGGACCGCCAGCCGCGCCGGCGTGCCGAT
CCTGCGCTATGACGACGCCTGGCTGCGCTCGCCCAACATGCGGCCGCTGTCGCTGTCGCTGCCGATCCCGGCCGGTGTGC
CCGAGCTGCGCGGCCAGGTGGTCGACGACTACTTCGACAACCTGCTGCCCGAGGCCCAGCCCATCCGCGAGCGCGTGCGG
CGCCGCTTCGGCCTCGCCTCCACGGATGCCGCCGAATTGCTGGCCGCCATCGGCCGCGACTGCGTGGGCGCCGTGCAACT
GCTGCCGCCCGGCATGGCCCCCACCGGCTACGATCGCATCGACAGCGAGCCGCTCACCGACAGCCAGGTCGACACGCTGC
TGCGCAACCTCACCGCCACGCCCGCGCTGGGCGAGGACGCCGGCGACCCCGACGCCTTCCGCATCTCCATTGCCGGCGCG
CAGGAGAAAACCGCCCTGCTGCGCATCGGCGATGCCTGGCACCGGCCGCTGGGCGCCACGCCCACCACGCACATCCTCAA
GCTGCCGCTGGGGCTGATCGGCAACATCCGCGCCGACATGCAGGACTCGGTCGACAACGAATGGCTGTGCGCGCAGCTGC
TGGCGGCCTGGGGGCTGGAGGTGGCGCGCACCGAGATCGCCCGCTTCGGCGCCAGCAAAGTGCTGGCGGTCGAGCGCTTC
GACCGCCGCTGGATGCCGGGCAACGCCTGGATCGCGCGCCTGCCGCAGGAAGACTTCTGCCAGGCTACAGGCACGCCCGC
GCACCGCAAATACGAAAACGACGGCGGCCCCGGCATGCGCGCCTGCCTCGACCTGCTGTCCGCGTCCGAACACGCCATCG
ACGACAAGCGCCGCTTCGTGCTGGCGCAACTTGCCTTCTGGCTGCTGGCCGCCACCGACGGGCACGCGAAGAACTTCTCG
CTGGCGATCGGGCGCGGCGGGCGCTTCCGCATGACGCCGCTGTATGACGTGCTCTCGGTCTGGCCGATCATGGGCGACGG
GCCGAACCAGCTGTCGCCCTATCGCGCGCGGCTGGCGATGGCCCTGCGCGGCAAGAACGCGCATGCGCGGCTGGCCGACA
TCCACGTGCGCCACTGGCAGGCGCTGGCAGCGCAATCCGGCGTGCCGGACGCGTTCGCCGGCATGCAGGCGCTGGTCGCG
CGCGTGCCGGCGGGTCTCGAGCGGGTCGAGGCGATCCTGCCGCCCGACTTCTCGGGCCGGGTCTGGAGCAGCGTGCGCAC
CGGCGTGCTCGCGCAGGCCGAGCGCTTTCTCAACGAACTGGCGTCCGTCACCCCATGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT181705 WP_000948331.1 NZ_CP064772:2277833-2278003 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT181705 NZ_CP086104:2138986-2139231 [Ralstonia sp. RS650]
ATGGAGTCCCTGCTCTCCTCGGCGCCGCAGCTGTCGGCGCATCTGAAATCGTTGCGCAAGGCGCGCGGACTCACGCAGGC
CCAGTTGGGCGCACTGCTGGGCGTCAGCCAGAACCGCATCGCCGACATCGAAAAAGACCCGGGCGCGGTCGGCTTCGAGC
AGTTGCTGCGCATCCTGCACGCGCTCGGCGCGCAGCTGACGCTGCGCACGTCCGCGCCCGCCGCCGCCGCGCCCGCCGAC
TGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1