Detailed information of TA system TA181640

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 2524790..2525496
• Replicon: chromosome
• Accession: NZ_CP064692
• Organism: Bradyrhizobium sp. 191

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: IVB23_RS11685
• Protein ID: WP_247803606.1
• Coordinates: 2525071..2525496 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IVB23_RS11680
• Protein ID: WP_247803605.1
• Coordinates: 2524790..2525074 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVB23_RS11660 (IVB23_11595)	2519843..2520817	-	975	WP_247803601.1	sugar ABC transporter permease	-
IVB23_RS11665 (IVB23_11600)	2520817..2521902	-	1086	WP_061878568.1	ABC transporter ATP-binding protein	-
IVB23_RS11670 (IVB23_11605)	2521915..2523054	-	1140	WP_061878569.1	ABC transporter ATP-binding protein	-
IVB23_RS11675 (IVB23_11610)	2523051..2524601	-	1551	WP_247803603.1	glycerol-3-phosphate dehydrogenase	-
IVB23_RS11680 (IVB23_11615)	2524790..2525074	+	285	WP_247803605.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IVB23_RS11685 (IVB23_11620)	2525071..2525496	+	426	WP_247803606.1	type II toxin-antitoxin system VapC family toxin	Toxin
IVB23_RS11690 (IVB23_11625)	2525500..2526345	-	846	WP_131866116.1	DeoR/GlpR family DNA-binding transcription regulator	-
IVB23_RS11695 (IVB23_11630)	2526453..2527139	-	687	WP_197967376.1	HAD-IA family hydrolase	-
IVB23_RS11700 (IVB23_11635)	2527294..2527746	+	453	WP_061878722.1	nuclear transport factor 2 family protein	-
IVB23_RS11705 (IVB23_11640)	2527885..2528076	-	192	WP_061878574.1	hypothetical protein	-
IVB23_RS11710 (IVB23_11645)	2528300..2528731	-	432	WP_061878723.1	acyl-CoA thioesterase	-
IVB23_RS11715 (IVB23_11650)	2528812..2529564	-	753	WP_247803609.1	fatty acid desaturase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (15-75)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15510.84 Da
• Isoelectric Point: 6.0791

>T181640 WP_247803606.1 NZ_CP064692:2525071-2525496 [Bradyrhizobium sp. 191]
VNLLLDTNVLSEVRRSAPSPKVLAWLDTIDEDRAFISVATIAELRRGIALLDDGRRRTALAAWLAHDLPARFADRVLPID
HAVAERWGDLMAQSRMGGVALSVMDGFFAATTLVHHLTLVTRNVKDFAAFGVPLLNPWDDA

Nucleotide

• Length: 426 bp

>T181640 NZ_CP086007:509127-509477 [Bacillus subtilis subsp. natto]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
CTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10260.60 Da
• Isoelectric Point: 7.0148

>AT181640 WP_247803605.1 NZ_CP064692:2524790-2525074 [Bradyrhizobium sp. 191]
MTDRITAPRTLPADDTWTLASAKARLSEVIDRAQAGPQVITRHGKPNAVVVSADEWARKTARNGTLAEFLLGSPLRGANL
ELERVQDAPRDEMP

Nucleotide

• Length: 285 bp

>AT181640 NZ_CP086007:508841-509122 [Bacillus subtilis subsp. natto]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCATATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA