Detailed information of TA system TA181574

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 3693340..3693562
• Replicon: chromosome
• Accession: NZ_CP064681
• Organism: Escherichia coli K-12 strain BZKR3G40

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: IVL00_RS17910
• Protein ID: WP_000141634.1
• Coordinates: 3693340..3693447 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3693496..3693562 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVL00_RS17885	3688593..3689345	-	753	Protein_3493	cellulose biosynthesis protein BcsQ	-
IVL00_RS17890	3689357..3689545	-	189	WP_001063318.1	YhjR family protein	-
IVL00_RS17895	3689818..3691389	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
IVL00_RS17900	3691386..3691577	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
IVL00_RS17905	3691574..3693253	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
IVL00_RS17910	3693340..3693447	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	3693496..3693562	+	67	-	-	Antitoxin
IVL00_RS17915	3693923..3695194	+	1272	WP_001295225.1	transporter	-
IVL00_RS17920	3695224..3696228	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
IVL00_RS17925	3696225..3697208	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
IVL00_RS17930	3697219..3698121	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T181574 WP_000141634.1 NZ_CP064681:c3693447-3693340 [Escherichia coli K-12]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T181574 NZ_CP085971:2476794-2477105 [Bordetella parapertussis]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT181574 NZ_CP064681:3693496-3693562 [Escherichia coli K-12]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin