Detailed information of TA system TA181349

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 717459..718300
• Replicon: chromosome
• Accession: NZ_CP064671
• Organism: Salmonella sp. SJTUF14152

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A1M0WJM1
• Locus tag: IVP15_RS03515
• Protein ID: WP_000854822.1
• Coordinates: 717917..718300 (+)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: B7MK11
• Locus tag: IVP15_RS03510
• Protein ID: WP_001285610.1
• Coordinates: 717459..717827 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVP15_RS03490	715203..716021	+	819	WP_001234702.1	DUF945 domain-containing protein	-
IVP15_RS03495	716112..716597	+	486	WP_072794436.1	antirestriction protein	-
IVP15_RS03500	716613..717089	+	477	WP_072661507.1	RadC family protein	-
IVP15_RS03505	717158..717379	+	222	WP_000692350.1	DUF987 domain-containing protein	-
IVP15_RS03510	717459..717827	+	369	WP_001285610.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IVP15_RS03515	717917..718300	+	384	WP_000854822.1	type IV toxin-antitoxin system toxin CbtA	Toxin
IVP15_RS03520	718291..718779	+	489	WP_001177592.1	hypothetical protein	-
IVP15_RS03525	718746..718988	+	243	WP_166635458.1	DUF957 domain-containing protein	-
IVP15_RS03530	719085..719930	+	846	WP_001280435.1	DUF4942 domain-containing protein	-
IVP15_RS03540	720230..720736	+	507	WP_000237776.1	G/U mismatch-specific DNA glycosylase	-
IVP15_RS03545	720860..722707	-	1848	WP_001519776.1	RNA polymerase sigma factor RpoD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	fosA3 / mph(E) / msr(E) / armA / sul1 / qacE / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3	rfaE	612202..762156	149954

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14295.32 Da
• Isoelectric Point: 8.2830

>T181349 WP_000854822.1 NZ_CP064671:717917-718300 [Salmonella sp. SJTUF14152]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN

Nucleotide

• Length: 384 bp

>T181349 NZ_CP085821:c4007876-4007601 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13606.39 Da
• Isoelectric Point: 6.0618

>AT181349 WP_001285610.1 NZ_CP064671:717459-717827 [Salmonella sp. SJTUF14152]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT181349 NZ_CP085821:c4008139-4007879 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Structures

Toxin

• AlphaFold DB: A0A1M0WJM1