Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2449028..2449550 Replicon chromosome
Accession NZ_CP064661
Organism Salmonella sp. SJTUF14178

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag IVP18_RS11890 Protein ID WP_000221343.1
Coordinates 2449266..2449550 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag IVP18_RS11885 Protein ID WP_000885424.1
Coordinates 2449028..2449276 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVP18_RS11865 2444670..2446136 + 1467 WP_023893409.1 hypothetical protein -
IVP18_RS11870 2446753..2447001 + 249 Protein_2322 helix-turn-helix domain-containing protein -
IVP18_RS11875 2447112..2448020 - 909 WP_077910000.1 hypothetical protein -
IVP18_RS11880 2448171..2448503 - 333 WP_023227504.1 DUF1493 family protein -
IVP18_RS11885 2449028..2449276 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IVP18_RS11890 2449266..2449550 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IVP18_RS11895 2449598..2449798 + 201 Protein_2327 RidA family protein -
IVP18_RS11900 2449850..2450929 - 1080 WP_023227502.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
IVP18_RS11905 2451122..2451610 - 489 WP_023227501.1 MarR family winged helix-turn-helix transcriptional regulator -
IVP18_RS11910 2451655..2453163 + 1509 WP_023227500.1 FAD-dependent oxidoreductase -
IVP18_RS11915 2453153..2454394 + 1242 WP_023227499.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2446185..2456020 9835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T181301 WP_000221343.1 NZ_CP064661:2449266-2449550 [Salmonella sp. SJTUF14178]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T181301 NZ_CP085818:1841781-1841884 [Salmonella enterica subsp. enterica serovar Enteritidis]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT181301 WP_000885424.1 NZ_CP064661:2449028-2449276 [Salmonella sp. SJTUF14178]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT181301 NZ_CP085818:c1841886-1841741 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References