Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3694513..3695187 Replicon chromosome
Accession NZ_CP064405
Organism Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag IRY56_RS17225 Protein ID WP_003417282.1
Coordinates 3694513..3694941 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag IRY56_RS17230 Protein ID WP_003417286.1
Coordinates 3694945..3695187 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IRY56_RS17200 3690335..3690736 - 402 WP_003417264.1 cytidine deaminase -
IRY56_RS17205 3690877..3691311 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
IRY56_RS17210 3691308..3691742 + 435 WP_003417269.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
IRY56_RS17215 3691871..3693643 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
IRY56_RS17220 3693643..3694434 + 792 WP_010950870.1 succinate dehydrogenase iron-sulfur subunit -
IRY56_RS17225 3694513..3694941 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
IRY56_RS17230 3694945..3695187 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
IRY56_RS17235 3695309..3695923 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
IRY56_RS17240 3695920..3696585 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
IRY56_RS17245 3696586..3697119 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
IRY56_RS17250 3697116..3697490 - 375 WP_003417295.1 4a-hydroxytetrahydrobiopterin dehydratase -
IRY56_RS17255 3697587..3698651 - 1065 WP_003913037.1 GTP 3',8-cyclase MoaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T181258 WP_003417282.1 NZ_CP064405:c3694941-3694513 [Mycobacterium tuberculosis variant bovis BCG]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T181258 NZ_CP085815:4339669-4340082 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT181258 WP_003417286.1 NZ_CP064405:c3695187-3694945 [Mycobacterium tuberculosis variant bovis BCG]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT181258 NZ_CP085815:4339422-4339688 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References