Detailed information of TA system TA181255

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3124524..3125072
• Replicon: chromosome
• Accession: NZ_CP064405
• Organism: Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0TFG5
• Locus tag: IRY56_RS14645
• Protein ID: WP_003414602.1
• Coordinates: 3124809..3125072 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: O33347
• Locus tag: IRY56_RS14640
• Protein ID: WP_003414599.1
• Coordinates: 3124524..3124805 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IRY56_RS14615	3120147..3121004	-	858	WP_003899513.1	type I methionyl aminopeptidase	-
IRY56_RS14620	3121046..3121630	-	585	WP_010950792.1	DUF1707 domain-containing protein	-
IRY56_RS14625	3121734..3121982	+	249	WP_003913411.1	antitoxin VapB23	-
IRY56_RS14630	3121979..3122359	+	381	WP_003414592.1	type II toxin-antitoxin system VapC family toxin	-
IRY56_RS14635	3122441..3124252	-	1812	WP_003414596.1	penicillin-binding protein	-
IRY56_RS14640	3124524..3124805	+	282	WP_003414599.1	type II toxin-antitoxin system antitoxin RelF	Antitoxin
IRY56_RS14645	3124809..3125072	+	264	WP_003414602.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IRY56_RS14650	3125445..3126299	-	855	WP_003899516.1	GNAT family N-acetyltransferase	-
IRY56_RS14655	3126355..3127518	-	1164	WP_003899517.1	flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase	-
IRY56_RS14660	3127535..3128749	-	1215	WP_011799297.1	zinc metalloprotease Rip	-
IRY56_RS14665	3128757..3129998	-	1242	WP_003414613.1	1-deoxy-D-xylulose-5-phosphate reductoisomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10204.82 Da
• Isoelectric Point: 11.5078

>T181255 WP_003414602.1 NZ_CP064405:3124809-3125072 [Mycobacterium tuberculosis variant bovis BCG]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Nucleotide

• Length: 264 bp

>T181255 NZ_CP085815:3714851-3715336 [Salmonella enterica subsp. enterica serovar Enteritidis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10183.40 Da
• Isoelectric Point: 4.3440

>AT181255 WP_003414599.1 NZ_CP064405:3124524-3124805 [Mycobacterium tuberculosis variant bovis BCG]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Nucleotide

• Length: 282 bp

>AT181255 NZ_CP085815:3714576-3714863 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Toxin

• PDB: 3G5O

Antitoxin

• PDB: 3G5O
• AlphaFold DB: A0A7U4BWP8