Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2186168..2187036 | Replicon | chromosome |
| Accession | NZ_CP064405 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain BCG SL 222 Sofia | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | IRY56_RS10030 | Protein ID | WP_010886136.1 |
| Coordinates | 2186168..2186545 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | IRY56_RS10035 | Protein ID | WP_003409886.1 |
| Coordinates | 2186587..2187036 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IRY56_RS09980 | 2181957..2182409 | - | 453 | WP_010950636.1 | lipoprotein | - |
| IRY56_RS09985 | 2182473..2182874 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| IRY56_RS09990 | 2182867..2183049 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| IRY56_RS09995 | 2183163..2183513 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| IRY56_RS10000 | 2183524..2184426 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| IRY56_RS10005 | 2184447..2184638 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| IRY56_RS10010 | 2184639..2184935 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| IRY56_RS10015 | 2185175..2185390 | + | 216 | WP_003409878.1 | antitoxin | - |
| IRY56_RS10020 | 2185387..2185698 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| IRY56_RS10025 | 2185672..2186193 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| IRY56_RS10030 | 2186168..2186545 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| IRY56_RS10035 | 2186587..2187036 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| IRY56_RS10040 | 2187033..2187578 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| IRY56_RS10045 | 2187467..2188081 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| IRY56_RS10050 | 2188130..2188426 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IRY56_RS10055 | 2188423..2188674 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| IRY56_RS10060 | 2188661..2189155 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| IRY56_RS10065 | 2189315..2189722 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| IRY56_RS10070 | 2189726..2189998 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| IRY56_RS10075 | 2190031..2191251 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T181234 WP_010886136.1 NZ_CP064405:2186168-2186545 [Mycobacterium tuberculosis variant bovis BCG]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T181234 NZ_CP085814:661632-661943 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT181234 WP_003409886.1 NZ_CP064405:2186587-2187036 [Mycobacterium tuberculosis variant bovis BCG]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT181234 NZ_CP085814:661944-662234 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|