Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 836782..837260 Replicon chromosome
Accession NZ_CP064383
Organism Escherichia coli O157:H7 strain PartA-EcoliO157H7-RM8376

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag IUJ36_RS03955 Protein ID WP_001303876.1
Coordinates 836782..837069 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag IUJ36_RS03960 Protein ID WP_000536233.1
Coordinates 837069..837260 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IUJ36_RS03925 (831931) 831931..834402 - 2472 WP_000034474.1 exonuclease -
IUJ36_RS03930 (834496) 834496..834687 - 192 WP_001098307.1 DUF1482 family protein -
IUJ36_RS03935 (834684) 834684..834872 - 189 WP_000413705.1 cell division inhibition protein DicB -
IUJ36_RS03940 (835446) 835446..835631 + 186 WP_001133046.1 hypothetical protein -
IUJ36_RS03945 (835818) 835818..836207 - 390 WP_000394511.1 hypothetical protein -
IUJ36_RS28220 (836219) 836219..836347 - 129 WP_000344963.1 protein YdfB -
IUJ36_RS03950 (836349) 836349..836504 - 156 WP_000379575.1 DUF1391 family protein -
IUJ36_RS03955 (836782) 836782..837069 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IUJ36_RS03960 (837069) 837069..837260 - 192 WP_000536233.1 hypothetical protein Antitoxin
IUJ36_RS03965 (837288) 837288..837689 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
IUJ36_RS03970 (837798) 837798..838070 + 273 WP_000887453.1 YdaS family helix-turn-helix protein -
IUJ36_RS03975 (838054) 838054..838479 + 426 WP_000693855.1 toxin YdaT family protein -
IUJ36_RS03980 (838686) 838686..839141 - 456 WP_000273724.1 hypothetical protein -
IUJ36_RS03985 (839220) 839220..840311 + 1092 WP_001205823.1 hypothetical protein -
IUJ36_RS03990 (840318) 840318..841064 + 747 WP_000788751.1 ATP-binding protein -
IUJ36_RS03995 (841086) 841086..841856 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T181036 WP_001303876.1 NZ_CP064383:c837069-836782 [Escherichia coli O157:H7]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T181036 NZ_CP085799:c4535663-4535136 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT181036 WP_000536233.1 NZ_CP064383:c837260-837069 [Escherichia coli O157:H7]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT181036 NZ_CP085799:c4535950-4535660 [Salmonella enterica subsp. enterica serovar Enteritidis]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References