Detailed information of TA system TA180814

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 1359303..1359780
• Replicon: chromosome
• Accession: NZ_CP064325
• Organism: Xylella fastidiosa subsp. multiplex strain Red Oak

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: IUD24_RS06015
• Protein ID: WP_004087087.1
• Coordinates: 1359514..1359780 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A7G7TPD2
• Locus tag: IUD24_RS06010
• Protein ID: WP_004091377.1
• Coordinates: 1359303..1359530 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IUD24_RS05975	1354495..1355055	-	561	WP_004084996.1	DUF2612 domain-containing protein	-
IUD24_RS05980	1355052..1356197	-	1146	WP_012337888.1	baseplate J/gp47 family protein	-
IUD24_RS05985	1356290..1356643	-	354	WP_012337889.1	hypothetical protein	-
IUD24_RS05990	1356640..1357281	-	642	WP_012337890.1	hypothetical protein	-
IUD24_RS05995	1357278..1358108	-	831	WP_004085000.1	hypothetical protein	-
IUD24_RS06000	1358105..1358422	-	318	WP_004085001.1	hypothetical protein	-
IUD24_RS06005	1358422..1359192	-	771	WP_012337891.1	hypothetical protein	-
IUD24_RS06010	1359303..1359530	+	228	WP_004091377.1	hypothetical protein	Antitoxin
IUD24_RS06015	1359514..1359780	+	267	WP_004087087.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IUD24_RS06020	1359791..1361680	-	1890	WP_012337892.1	hypothetical protein	-
IUD24_RS06025	1361637..1361801	-	165	WP_014607750.1	hypothetical protein	-
IUD24_RS06030	1361828..1362250	-	423	WP_012337893.1	hypothetical protein	-
IUD24_RS06035	1362247..1362684	-	438	WP_004085006.1	DUF3277 family protein	-
IUD24_RS06040	1362694..1364190	-	1497	WP_012337894.1	DUF3383 domain-containing protein	-
IUD24_RS06045	1364191..1364724	-	534	WP_004085008.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1353247..1375869	22622

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10207.80 Da
• Isoelectric Point: 10.3398

>T180814 WP_004087087.1 NZ_CP064325:1359514-1359780 [Xylella fastidiosa subsp. multiplex]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCDIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T180814 NZ_CP085743:c2889666-2889346 [Enterobacter hormaechei]
ATGAATATTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGCAAATGTTACTGGC
AAGCCTGCTAGACCAGCACTATGGCCTCACGCTAAACGACACGCCGTTTAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCCGATGCCGTAAATTTTCTGGTTGAACGCTATGAACTAGTTCGTATTGACCAAAAAGGCTAC
TCTGTGCAAGATCAGGAACCTTGGTTAACTTATATGGATGTCCACCGAGCACAACTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8615.63 Da
• Isoelectric Point: 5.0958

>AT180814 WP_004091377.1 NZ_CP064325:1359303-1359530 [Xylella fastidiosa subsp. multiplex]
MATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLGLDD

Nucleotide

• Length: 228 bp

>AT180814 NZ_CP085743:c2890013-2889687 [Enterobacter hormaechei]
ATGTCATTAATACCAGCCCATGAATGGGGGCTAAAAAGCGATATTGTTCCACGGTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTGCATTTTCTGGCTGACAGGGCTAGTTTGATGGGCAATTTTAGCGATACGGAATGCTTCAAATTGAATGACG
CATTTCCACACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAACTGATCCCCTGTCACCATCGCTGTGTCACT
CTCTACCATAACGGTTTTACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCGGTTTACTCAACTCA
ACGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A7G7TPD2