Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1325110..1325674 Replicon chromosome
Accession NZ_CP064316
Organism Lacticaseibacillus paracasei subsp. tolerans strain MGB0761

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag LacP0761_RS06720 Protein ID WP_016363448.1
Coordinates 1325372..1325674 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag LacP0761_RS06715 Protein ID WP_003570051.1
Coordinates 1325110..1325379 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LacP0761_RS06685 1320115..1321002 - 888 WP_003570041.1 ABC transporter ATP-binding protein -
LacP0761_RS06690 1321199..1322425 - 1227 WP_003570043.1 hypothetical protein -
LacP0761_RS06695 1322623..1323027 + 405 WP_003570045.1 MerR family transcriptional regulator -
LacP0761_RS06700 1323020..1323346 + 327 WP_003584272.1 YrdB family protein -
LacP0761_RS06705 1323409..1324038 + 630 WP_003570047.1 DUF2399 domain-containing protein -
LacP0761_RS06710 1324083..1324736 + 654 WP_003570049.1 GNAT family N-acetyltransferase -
LacP0761_RS06715 1325110..1325379 + 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LacP0761_RS06720 1325372..1325674 + 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
LacP0761_RS06725 1326013..1326156 + 144 WP_162259784.1 hypothetical protein -
LacP0761_RS06730 1326274..1326966 + 693 WP_003570055.1 hypothetical protein -
LacP0761_RS06735 1327202..1329379 + 2178 WP_003570057.1 RNA-binding transcriptional accessory protein -
LacP0761_RS06740 1329804..1330361 - 558 WP_003584278.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T180805 WP_016363448.1 NZ_CP064316:1325372-1325674 [Lacticaseibacillus paracasei subsp. tolerans]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

>T180805 NZ_CP085740:c4710258-4709725 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT180805 WP_003570051.1 NZ_CP064316:1325110-1325379 [Lacticaseibacillus paracasei subsp. tolerans]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp

>AT180805 NZ_CP085740:c4710535-4710269 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References