Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3056498..3057170 Replicon chromosome
Accession NZ_CP064121
Organism Yersinia pestis strain M-1482

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag ISU58_RS13925 Protein ID WP_002215144.1
Coordinates 3056498..3056923 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag ISU58_RS13930 Protein ID WP_002209939.1
Coordinates 3056904..3057170 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISU58_RS13905 3052150..3052668 + 519 WP_002209934.1 flavodoxin FldB -
ISU58_RS13910 3052758..3054215 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
ISU58_RS13915 3054357..3055775 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
ISU58_RS13920 3055800..3056498 - 699 WP_002209937.1 two-component system response regulator CreB -
ISU58_RS13925 3056498..3056923 - 426 WP_002215144.1 protein YgfX Toxin
ISU58_RS13930 3056904..3057170 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
ISU58_RS13935 3057487..3058479 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
ISU58_RS13940 3058552..3059049 - 498 WP_002209941.1 DUF2165 family protein -
ISU58_RS13945 3059307..3060008 - 702 WP_002209942.1 hemolysin III family protein -
ISU58_RS13950 3060210..3061313 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T180258 WP_002215144.1 NZ_CP064121:c3056923-3056498 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T180258 NZ_CP085094:1163394-1163690 [Aggregatibacter actinomycetemcomitans]
ATGAGTGAACAATTGAAAGATTTTGATCCTGCAGAATATTTATCTACCGAAGAAGATATTCGGCTTTATTTAAATGAAGT
GCTACAAGAAAATAATATTGAGCTTATTTTGTCTGCGTTAGGCGATATCGCACGAACCAGAAATATGAGCCAAATTGCCC
GCGAAACCGGTATGAGTAGAGAAGGGCTTTATAAAGCCCTGTCCGGTACGGGCAATCCTACCTTTGCCACCGTGATTAAA
GTCATGAAAGCCTTAAATTTACAACTCCAAGTGCAACCTTCCGGTTATGTTTCTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT180258 WP_002209939.1 NZ_CP064121:c3057170-3056904 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT180258 NZ_CP085094:1163098-1163397 [Aggregatibacter actinomycetemcomitans]
ATGATGATACAAATTAAGACGACTTTTCTTTTTGATGAATGGTTGAAGAAACTCAAAAACCTAAGAGCTAAAGCAAAAAT
CAACGCACGAATTAAACGGTTACAGTTTGGTAATTTCGGTGATTTAAAAAGCGTTAATGACGGCATATTTGAAATGCGGA
TTGATAAAGGTCAGGGGTATCGGGTTTATCTGAAAAATCAAAATGGCATACTTGTTATCCTGCTTTGTGGCGGAGACAAA
TCCACTCAAGAGAAAGATATCAAGAAAGCAAAACAACTTGCACAGGAAATGGGACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References