Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 830343..831177 Replicon chromosome
Accession NZ_CP063983
Organism Escherichia coli strain 25DN

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag IR210_RS03990 Protein ID WP_000854688.1
Coordinates 830343..830720 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag IR210_RS03995 Protein ID WP_001285596.1
Coordinates 830797..831177 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IR210_RS03960 825894..826828 - 935 Protein_778 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
IR210_RS03965 826821..827216 - 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
IR210_RS03970 827285..828130 - 846 WP_001280441.1 DUF4942 domain-containing protein -
IR210_RS03975 828414..829433 - 1020 WP_000875213.1 IS110 family transposase -
IR210_RS03980 829647..829844 - 198 WP_000839260.1 DUF957 domain-containing protein -
IR210_RS03985 829861..830346 - 486 WP_194446244.1 hypothetical protein -
IR210_RS03990 830343..830720 - 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
IR210_RS03995 830797..831177 - 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IR210_RS04000 831227..831870 - 644 Protein_786 antitoxin of toxin-antitoxin stability system -
IR210_RS04005 831889..832110 - 222 WP_000692329.1 DUF987 domain-containing protein -
IR210_RS04010 832173..832650 - 478 Protein_788 RadC family protein -
IR210_RS04015 832666..833151 - 486 WP_000849564.1 antirestriction protein -
IR210_RS04020 833206..834024 - 819 WP_194446245.1 DUF945 domain-containing protein -
IR210_RS04025 834125..834358 - 234 WP_001119727.1 DUF905 family protein -
IR210_RS04030 834437..834892 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF 807296..833151 25855
- flank IS/Tn - - 828414..829433 1019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T179889 WP_000854688.1 NZ_CP063983:c830720-830343 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T179889 NZ_CP084898:c1270016-1269909 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT179889 WP_001285596.1 NZ_CP063983:c831177-830797 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT179889 NZ_CP084898:1270064-1270130 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References