Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2572600..2573219 Replicon chromosome
Accession NZ_CP063939
Organism Klebsiella pneumoniae strain BM343

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag ISA62_RS12530 Protein ID WP_002892050.1
Coordinates 2573001..2573219 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag ISA62_RS12525 Protein ID WP_002892066.1
Coordinates 2572600..2572974 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA62_RS12515 2567752..2568945 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
ISA62_RS12520 2568968..2572114 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
ISA62_RS12525 2572600..2572974 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
ISA62_RS12530 2573001..2573219 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
ISA62_RS12535 2573378..2573944 + 567 WP_002892030.1 maltose O-acetyltransferase -
ISA62_RS12540 2573916..2574056 - 141 WP_032409038.1 hypothetical protein -
ISA62_RS12545 2574077..2574547 + 471 WP_002892026.1 YlaC family protein -
ISA62_RS12550 2574522..2575928 - 1407 WP_004167590.1 PLP-dependent aminotransferase family protein -
ISA62_RS12555 2576073..2576771 + 699 WP_019705329.1 GNAT family N-acetyltransferase -
ISA62_RS12560 2576768..2576908 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
ISA62_RS12565 2576908..2577171 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T179745 WP_002892050.1 NZ_CP063939:2573001-2573219 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T179745 NZ_CP084892:c2172956-2172747 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT179745 WP_002892066.1 NZ_CP063939:2572600-2572974 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT179745 NZ_CP084892:c2173261-2172968 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References