Detailed information of TA system TA179415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 2618586..2620267
• Replicon: chromosome
• Accession: NZ_CP063912
• Organism: Klebsiella variicola strain BS359-2-1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A7H4S924
• Locus tag: ISA79_RS12640
• Protein ID: WP_012969143.1
• Coordinates: 2618586..2619503 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A0B7GCX3
• Locus tag: ISA79_RS12645
• Protein ID: WP_008807257.1
• Coordinates: 2619509..2620267 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISA79_RS12620	2613892..2615412	+	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-
ISA79_RS12625	2615409..2616407	+	999	WP_023296904.1	ribose ABC transporter permease	-
ISA79_RS12630	2616438..2617379	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
ISA79_RS12635	2617454..2618461	+	1008	WP_043875932.1	carbohydrate kinase family protein	-
ISA79_RS12640	2618586..2619503	-	918	WP_012969143.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
ISA79_RS12645	2619509..2620267	-	759	WP_008807257.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
ISA79_RS12650	2620352..2621080	-	729	WP_043875934.1	response regulator transcription factor	-
ISA79_RS12655	2621353..2623500	+	2148	WP_077598974.1	formate dehydrogenase subunit alpha	-
ISA79_RS12660	2623854..2624540	+	687	WP_131026269.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34721.11 Da
• Isoelectric Point: 5.4707

>T179415 WP_012969143.1 NZ_CP063912:c2619503-2618586 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T179415 NZ_CP084741:3413429-3413749 [Pectobacterium carotovorum]
ATGCAAACATCACCTGCAATCCCGCCACGGGAGGATATCCCTTGCCCGTCACCTGTAGTCGTCTGGCAGCAACTTCTGAC
CTATCTACTGGAAAAGCACTACGGCCTCACGCTGAACGACACACCGTTCTGCGAGGAAAACGTGATTCAGGAGCATATCG
ATGCTGGCATCACGTTGGTCAATGCGGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGATCGCAACGGCTTT
AACTGGCAGGAGCAATCGCCGTTTCTCACTACTGTCGATATCCTTCGCGCCAGACGTGCAACAGGTTTACTTAAGGCATA
A

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28653.01 Da
• Isoelectric Point: 10.1988

>AT179415 WP_008807257.1 NZ_CP063912:c2620267-2619509 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT179415 NZ_CP084741:3413024-3413359 [Pectobacterium carotovorum]
ATGCCATCATCGGATACCCCGGAATGGGGACTAAAATGTGCTATCACGCCGCGATTCGGGGCACGACTGGTTCAGGAAGG
TAACCGTCTGCATTATCTGGCAGATCGGGCCAGCATTGTCGGTACGTTCAGCAAAACAGAAGCCCAAAGTCTGGAACGTT
GCTTCCCTGAGCTGATTAAGCTGTTGGAGCAGAAGCTACGCACGGGTGAACTGAATCCCCGCCAGCAAGGCTGCGTCACA
CTGCGTTGCAACGAATGGACCTGTAAAGCCGATACGCTGGGCAGCTTTGGCTACGTGTATATTGTTATTTATCCCTCTTC
GGCGGCAACACAATAA

Structures

Toxin

• AlphaFold DB: A0A7H4S924

Antitoxin

• AlphaFold DB: A0A0B7GCX3