Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 102926..104514 Replicon chromosome
Accession NZ_CP063902
Organism Klebsiella quasipneumoniae strain BS419-3

Toxin (Protein)


Gene name hipA Uniprot ID A0A5Q9LEV0
Locus tag ISA85_RS00510 Protein ID WP_043519554.1
Coordinates 102926..104248 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2A5MFC9
Locus tag ISA85_RS00515 Protein ID WP_004205921.1
Coordinates 104248..104514 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA85_RS00475 98008..98226 + 219 WP_002904808.1 ParD-like family protein -
ISA85_RS00480 98207..98989 + 783 WP_049003659.1 type I methionyl aminopeptidase -
ISA85_RS00485 99258..100373 + 1116 WP_004205914.1 serine hydrolase -
ISA85_RS00490 100360..100704 + 345 WP_004205915.1 hypothetical protein -
ISA85_RS00495 100733..101266 + 534 WP_004205916.1 hypothetical protein -
ISA85_RS00500 101269..101475 + 207 WP_004205917.1 helix-turn-helix transcriptional regulator -
ISA85_RS00505 101617..102909 + 1293 WP_023318214.1 glycoside hydrolase family 10 protein -
ISA85_RS00510 102926..104248 - 1323 WP_043519554.1 type II toxin-antitoxin system HipA family toxin Toxin
ISA85_RS00515 104248..104514 - 267 WP_004205921.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
ISA85_RS00520 104797..105123 - 327 WP_064794852.1 hydroxyisourate hydrolase -
ISA85_RS00525 105120..105620 - 501 WP_017900378.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
ISA85_RS00530 105598..106977 - 1380 WP_017900377.1 purine permease -
ISA85_RS00535 107323..108477 + 1155 WP_053810396.1 FAD-dependent urate hydroxylase HpxO -
ISA85_RS00540 108458..109381 - 924 WP_053810397.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48998.30 Da        Isoelectric Point: 8.2655

>T179304 WP_043519554.1 NZ_CP063902:c104248-102926 [Klebsiella quasipneumoniae]
MATLTTWMNNARVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRERIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIINTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILGEFADRVP
QAIESARQTLPSDFSAHVWRAITENMLKLHARLQQGLLAG

Download         Length: 1323 bp

>T179304 NZ_CP084667:428-1468 [Hafnia paralvei]
ATGGCACAGAACCCATTTAAAGCACTAAATATCAATACAGACAAGATTGAAGCTGCTCTGACGCAGAATGGCGTCACAAA
CTTTTCTTCTACCGTGAAAAACGAAAGAGAGACGCATTTATCAGGGACATATAAAGAAATAGATTTTTTAATAAAGCTAA
TGCCATCAGGTGGAAACACCACTATAGGAAAGGCATCAGGGCAAAACAATACTTACTTTGATGAGATCGCTGGCATTATA
AAAGAAAATTGTTTGTATTCAGATAAAAAAACTTTTGAATACACCATCCCAAGATTCAGCGATGAAAATAAGGAAATGTT
ATTTTCATTTCTTGCTGAAGAAAACGTAAAAATAGAAGAAGATCAAAACAACGATCCTAACTGCAAGCATCAATACATCA
TGACCACTGGTAATGGTGACAGAGTCAGAGCGAAAATTTACAACCGTGGTTCAATTCAATTCCAAGGAAAATATCTTCAA
ATCGCAAGTTTGATTAATGATTTCATGTGCACCATACTGGACATGAAAGATATTATAAAACAGAAGAATCAAGAATTTAA
TGTTGACATAAAAAAAGAAACAATTGAGTCAGAATTACATAGTAAACTCCCAAAAAGCATCGACCAAATCCATGACGACA
TCAAAAAACAGCTATCCTGCTCGCTCATAATGAAAAAAATAGATGTCGAAATGGAAGATTACTCAACGTATTGTTTCTCA
GCTTTAAGATCTGTGGAAGGCTTTATATATCAGCTACTTGGAAGTATATGCAATCCATCATCATCAAGAAATCTTGGCGA
GTACTTTACTGAGAATAACCCGAAATACATAATAAGAGATATACACCAAGAAACTATTAATGGTGAAATAGCAGAAGTTT
TGTGTGAGTGCTACACTTACTGGCATGAAAACAGACATGGTTTGTTCCATATGAAACCAGGTGTGGCTGACACTAAGACA
ATTGACAAAGCAGAATCTATTGAAATTATCGATACTGTATGTCAGTTGATAGATAACGGCATAGCTAGGTTGAAATCATG
A

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9940.38 Da        Isoelectric Point: 7.1997

>AT179304 WP_004205921.1 NZ_CP063902:c104514-104248 [Klebsiella quasipneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETAMIP
DNTTDLDW

Download         Length: 267 bp

>AT179304 NZ_CP084667:1465-1845 [Hafnia paralvei]
ATGAAAATAAACAAAAAATATCAAATAGAGGTGATGAAGGATAAAGATAAAACTTTATTCATTGTCTACGCTACAGATAT
TTACAGCCCGAGCGAATTTTTCTCTAAAATCGAGTCTGATTTAAAGAAAAAGAAAGTTGGGGGCGATGTTTTTTTTGATT
TAATAATTCCTAATGGTGGAAAAAAAGACCGTTACGTCTATACATCATTCAATGGCGAACGATTAACAAGCTACATATTA
AACAAAGTTACGGAAACAGATGAGTATAAATCCTTATCTGAACGCTCAGCTTCGTTCTTTAAAAAAAACTTTGATAAGAT
TAATGCAAACCTTCTATCTAAAGCCACATCGTTTGCTTTAAAACAAGGCATTCCAATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LEV0

Antitoxin

Source ID Structure
AlphaFold DB A0A2A5MFC9

References