Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3656262..3656775 Replicon chromosome
Accession NZ_CP063900
Organism Klebsiella quasipneumoniae strain BS324-2

Toxin (Protein)


Gene name relE Uniprot ID A0A663BE04
Locus tag ISA86_RS17845 Protein ID WP_017900571.1
Coordinates 3656494..3656775 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag ISA86_RS17840 Protein ID WP_002886901.1
Coordinates 3656262..3656504 (+) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISA86_RS17825 3652292..3653032 + 741 WP_004206507.1 KDGP aldolase family protein -
ISA86_RS17830 3653100..3654251 + 1152 WP_057212389.1 lactonase family protein -
ISA86_RS17835 3654274..3656184 + 1911 WP_109938334.1 BglG family transcription antiterminator -
ISA86_RS17840 3656262..3656504 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
ISA86_RS17845 3656494..3656775 + 282 WP_017900571.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISA86_RS17850 3656779..3657243 - 465 WP_032456904.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
ISA86_RS17855 3657542..3657853 - 312 WP_109938332.1 hypothetical protein -
ISA86_RS17860 3657980..3660118 - 2139 WP_080838453.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 11082.93 Da        Isoelectric Point: 10.4123

>T179298 WP_017900571.1 NZ_CP063900:3656494-3656775 [Klebsiella quasipneumoniae]
MTYELEFDPRAWREWQLGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDRVVVVYVIAIGKR
EKAAVYHQANKRL

Download         Length: 282 bp

>T179298 NZ_CP084664:462607-462930 [Hafnia paralvei]
ATGAAAATTCTACCGGCTACAATTTCGCGGGCGGCGAAGCCCTGCCTGCCACCCGTTGCAGTCTGGCAATTGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCAGTGATGAAACCGTTATAAAGGAACATTTCG
ATGCCGGTATCACTCTCGCTAATGCCATTAACTTTCTAGTGGAAAAGTACGAACTGGTTCGTATCGATCGCAGAGGGTTT
AGCTGGCAAGAACAAACGCCATATCTCACGAATATTGATATCATGAGGGCCCGCCGCGATCTGGGTTTATTAAATCGTAA
TTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT179298 WP_002886901.1 NZ_CP063900:3656262-3656504 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT179298 NZ_CP084664:462269-462586 [Hafnia paralvei]
ATGAGCAACATCATTTGGGGCCTGCAGCGCGATATCACGCCGCGCCTGGGAACACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTACCTGGCTGACCGGGCCTGTATCACAGGTAAGTTCAGTGATGCCGAATGTCTTAAGCTGGATGTGGCATTTCCGC
ATTTTATCAGCCGGATGGAATCCATGCTGAGCACGGGTGAAATGAATCCTCGCCACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGTGGCTATGTATACGTCGCTGTTTATTCCACTCAGCGCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A663BE04


Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References