Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2905461..2906107 Replicon chromosome
Accession NZ_CP063889
Organism Klebsiella variicola strain BS325-3-1

Toxin (Protein)


Gene name higB Uniprot ID A0A1F2M0N0
Locus tag ISB13_RS13780 Protein ID WP_008806991.1
Coordinates 2905461..2905808 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1F2LZT5
Locus tag ISB13_RS13785 Protein ID WP_008806992.1
Coordinates 2905808..2906107 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISB13_RS13770 2901348..2902781 + 1434 WP_004202133.1 glycogen synthase GlgA -
ISB13_RS13775 2902799..2905246 + 2448 WP_008806990.1 glycogen phosphorylase -
ISB13_RS13780 2905461..2905808 + 348 WP_008806991.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ISB13_RS13785 2905808..2906107 + 300 WP_008806992.1 helix-turn-helix transcriptional regulator Antitoxin
ISB13_RS13790 2906170..2907678 - 1509 WP_008806993.1 glycerol-3-phosphate dehydrogenase -
ISB13_RS13795 2907882..2908211 + 330 WP_023291211.1 thiosulfate sulfurtransferase GlpE -
ISB13_RS13800 2908262..2909092 + 831 WP_008806994.1 rhomboid family intramembrane serine protease GlpG -
ISB13_RS13805 2909142..2909900 + 759 WP_008806995.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13504.52 Da        Isoelectric Point: 6.2327

>T179223 WP_008806991.1 NZ_CP063889:2905461-2905808 [Klebsiella variicola]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFGPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T179223 NZ_CP084650:3082368-3082724 [Yersinia ruckeri]
ATGAAACCACGCCCCACAGCGCAGGGTGCATTGCCCGTGCCTGTTATTTATCAACAACTGCTCGCTTTTCTGCTGGAGCA
CCACTATGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGCGATTGCACAACAGATAGAACAAGGGATTTCAG
TCGGTGACACCATTAATGCCCTGGTTGAGAAATATGCCTTAGTGCAAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTAAGCAAAGGCGATATCGTGCGGGCTCGCCAGGCTTCGGGCTTGTGGCGTGCTCATTTTCCACCCACGTT
GCTGTACCCAACCGAGTCCCTCAATCCTATTCCATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10814.61 Da        Isoelectric Point: 10.1464

>AT179223 WP_008806992.1 NZ_CP063889:2905808-2906107 [Klebsiella variicola]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT179223 NZ_CP084650:3082736-3083068 [Yersinia ruckeri]
ATGAATAACCACATTACGACTTCCCCAACATGGGGCCTGAAACGTGATATTACGCCGCGGTTGGGAGCCCGACTGGTACA
GGAGGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCGCTCAGGCTCTTG
ATGTGGCATTCCCAGCGCTGATAACCAAACTGGAGTCGCAGTTGCTGTCCGGTCAGCTTGACCCTCGCCGTCAGCAGTGC
CTTACGGTCCGGCACGGGGGATTTGTCTGTGACGCCGATACGCTGGGCAGTCACGGTTATGTCTATATCGCGGTGTATCA
GGAACTGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2M0N0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZT5

References