Detailed information of TA system TA179191

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2511826..2512506
• Replicon: chromosome
• Accession: NZ_CP063885
• Organism: Klebsiella pneumoniae strain BS361-1

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: ISB15_RS12085
• Protein ID: WP_174239183.1
• Coordinates: 2512192..2512506 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1X3RMB8
• Locus tag: ISB15_RS12080
• Protein ID: WP_064164243.1
• Coordinates: 2511826..2512149 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ISB15_RS12050	2507320..2508195	+	876	WP_032413278.1	GTPase family protein	-
ISB15_RS12055	2508408..2509109	+	702	WP_194429438.1	WYL domain-containing protein	-
ISB15_RS12060	2509115..2509762	+	648	WP_194429437.1	hypothetical protein	-
ISB15_RS12065	2509931..2510341	+	411	WP_102054331.1	hypothetical protein	-
ISB15_RS12070	2510451..2511272	+	822	WP_194429436.1	DUF945 domain-containing protein	-
ISB15_RS12075	2511343..2511813	+	471	WP_064164242.1	DNA repair protein RadC	-
ISB15_RS12080	2511826..2512149	+	324	WP_064164243.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
ISB15_RS12085	2512192..2512506	+	315	WP_174239183.1	TA system toxin CbtA family protein	Toxin
ISB15_RS12090	2512620..2513453	+	834	WP_064164245.1	DUF4942 domain-containing protein	-
ISB15_RS12095	2513904..2514410	-	507	WP_019704403.1	YrhA family protein	-
ISB15_RS12100	2514421..2515554	-	1134	WP_032413284.1	HNH endonuclease	-
ISB15_RS12105	2515759..2516381	-	623	Protein_2342	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2494190..2520264	26074

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (9-102)

Antitoxin

• Antitoxin CbeA (7-106)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11730.22 Da
• Isoelectric Point: 5.5157

>T179191 WP_174239183.1 NZ_CP063885:2512192-2512506 [Klebsiella pneumoniae]
ISTVPAKVPVSSRPSPVQVWQQLLTYLLDHHYGLTLNDTPFHDDGAIEEHIDAGITLADAVNFLVERYELVRIDRKGFSW
QEQTPFLTATDILRARRATGLTNT

Nucleotide

• Length: 315 bp

>T179191 NZ_CP084643:465508-466164 [Yersinia ruckeri]
GTGGCCTATGACTACAGCACTAGCCTCAACCCGGAAAAAGCCTTGATCTGGCGCATTGTCCATCGGGACAATATTCCGTG
GATACTGGACAACGGTCTGCACTGTGGCAACAGTCCGGTGCAGGCGGAAGACTGGATTAATATCGGTAACCCGGAGCTTA
TCGACAAACGTGCCGGACATCTGGTGCCAACCGGAATGCGGGGGACGCTGCATGACTATGTGCCGTTTTACTTTACTCCT
TTCTCGCCGATGCTGATGAATATCCGCAGCGGACGTGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGTAGCCTGCGAAACATGGTGGCGCAAAATGTCTCCTTCGTGTTTACCGATAGCCACGCATATTATAACCTGGCTAATT
ACTTTACCGAGCTGGACAGTCTGAACCAGATCGATTGGCCCATTCTACAAGCGCGGGATTTCCGTCGCGATCAGGACGAT
TTGGCCAAGTTCGAACGCTATCAGGCAGAGGCGTTAATTTGGAAGCACTGCCCAATAGCGCTGCTTGGCGGGATGATTTG
TTACAACGATGGCGTCAGGTTACAATTAGAGCAGTGGTTGTCGCAACGCAATCTGTCAATGCCCGTTCACGCGCGGGCTG
GGTGGTACTTCTCATGA

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 11968.77 Da
• Isoelectric Point: 5.5306

>AT179191 WP_064164243.1 NZ_CP063885:2511826-2512149 [Klebsiella pneumoniae]
MSITPPHEWGLQSDITPRFAARLVQEGNRLYYLADRAGLTGSFSPMHLQKLDLAFPLFVEQLEDMLCAGELNPHQQRQVK
IQLASLTCIADTLGSCGYVYISIYPTP

Nucleotide

• Length: 324 bp

>AT179191 NZ_CP084643:466161-467228 [Yersinia ruckeri]
ATGATTACATTTACACAAGGCAATTTACTGGATGCGCCCGTAGAAGCACTAGTGAATACGGTTAATACCGTCGGTGTCAT
GGGTAAAGGCATCGCGCTGATGTTCAAAGAGCGCTTCCCCGTCAATATGAAAGCCTATGCTCTCGCCTGCAAACATAAGC
AGGTAATGACAGGTAAAATGTTTATTACCGAAACCGGCGAACTGATGGGGCCTCGCTGGATTGTCAACTTCCCAACTAAA
CAACACTGGCGCGCAGACTCCCGCATGGAGTGGGTTGAAGACGGCTTGCAGGATTTACGCCGCTTTTTGATCGAAGAGAA
AGTGCAATCTATCGCCATTCCCCCACTGGGGGCGGGTAACGGCGGCCTGAATTGGTCGGACGTTCGGATGCGGATTGAAT
CTGCGCTGGGCGACCTTCAGGACACGGAAATTCTGATTTATGAGCCTACCGAAAAATACCAGAACGTCGCCAAGAGCACC
GGCGTAAAAAAGCTCACTCCCGCCAGAGCGCTGATTGCTGAACTGGTGCGCCGCTACTGGGTGCTGGGCATGGAGTGCAG
CCTGCTGGAAATCCAGAAGCTGGCATGGCTGTTACAACGCGCCATTGAACAGCATCAGCAGGAAGATGTGCTGAAACTGC
GGTTTGAGGCGCACTATTACGGCCCCTACGCCCCCAACCTTAACCATCTGCTTAACGCGCTAGATGGCACGTATCTGAAA
GCAGAGAAACGCATCCCGGACACCCAGCCGCTGGATGTGATCTGGTTTAATGATCAGGAAAAAGAACACATCAACCTCTG
GCTGAACAACGAGGCCAAAGAGTGGCTACCGGCGCTTGAGCAGGTCAGTCAGTTGATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGCTGCTGGCAACCGTTGACTGGCTGCTGACCCGAGGAAAATGCCAGCCCACGCTGGATTCCGTGAAAGAGGGG
CTGCACCAGTGGCCTGCGGGTGAACGCTGGGCCAGCCGTAAGATGAAGCTCTTTGACGACAAGAATCTGCAATTTGCCAT
CAACCGCGTGATGGAGTTCCATTGCTAA

Structures

Antitoxin

• AlphaFold DB: A0A1X3RMB8