Detailed information of TA system TA179121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 2069098..2070436
• Replicon: chromosome
• Accession: NZ_CP063874
• Organism: Klebsiella quasipneumoniae strain S174-1

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: A0A483NH02
• Locus tag: IOD26_RS10170
• Protein ID: WP_004186795.1
• Coordinates: 2069098..2070048 (-)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A1W6B2R8
• Locus tag: IOD26_RS10175
• Protein ID: WP_004186793.1
• Coordinates: 2070041..2070436 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IOD26_RS10155	2065325..2067004	+	1680	WP_017900969.1	glycoside hydrolase family 43 protein	-
IOD26_RS10160	2067086..2067724	-	639	WP_080847944.1	HNH endonuclease	-
IOD26_RS10165	2067904..2068773	+	870	WP_200983429.1	HNH endonuclease	-
IOD26_RS10170	2069098..2070048	-	951	WP_004186795.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
IOD26_RS10175	2070041..2070436	-	396	WP_004186793.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
IOD26_RS10180	2070511..2071344	-	834	WP_087775048.1	DUF4942 domain-containing protein	-
IOD26_RS10185	2071458..2071778	-	321	WP_004186789.1	TA system toxin CbtA family protein	-
IOD26_RS10190	2071815..2072138	-	324	WP_200983431.1	type IV toxin-antitoxin system YeeU family antitoxin	-
IOD26_RS10195	2072151..2072621	-	471	WP_004186785.1	DNA repair protein RadC	-
IOD26_RS10200	2072692..2073513	-	822	WP_200983433.1	DUF945 domain-containing protein	-
IOD26_RS10205	2073623..2074084	-	462	WP_200983610.1	hypothetical protein	-
IOD26_RS10210	2074202..2074831	-	630	WP_004186778.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (36-304)

Antitoxin

• Protein of unknown function DUF6088 (7-114)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 36069.47 Da
• Isoelectric Point: 4.6461

>T179121 WP_004186795.1 NZ_CP063874:c2070048-2069098 [Klebsiella quasipneumoniae]
MDDLTKLFPDVADALGIESVAIVEKDHYIVELLRLLQPLSFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVTGFSL
QYSRNQRKNIRKDIIKTITETIVASGMFSMDEEYPKVTRDENRYNEIPVRYPQEYVQIPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGAEVPVLKRFV
QECIEQDIQRYGAQYPEFCESPVEELKMGLEELASNPVYKERYLQFVTPMVFGESHVSWEEAYACFRITALDVIDA

Nucleotide

• Length: 951 bp

>T179121 NZ_CP084578:111003-111263 [Sulfurimonas sp. SWIR-19]
ATGAAATTTGAATATGATATAAAAAAGAGCTTATCAAATAAGCAAAAACACGGTATTGATTTTGAAGAAGCTAAACTTCT
TTGGAATGATGACAATATGGTTGAAATTAGAACATCTTACGAAGATGAAGAAAGATTTATCACTATTGGCAAGATTACTG
CAAAAATTTATGCAGTAGTAACAACATACCGTAAAGAAAATATAAGAATTATATCTGCACGAAGAGCAAGAAAAAAGGAG
ATTGAAATCTATGAAAGCTGA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14400.75 Da
• Isoelectric Point: 11.0360

>AT179121 WP_004186793.1 NZ_CP063874:c2070436-2070041 [Klebsiella quasipneumoniae]
MTIKARIQSRLKRSKRYVFTRDDFKDLAGYDQIGRALRELMKEGQLLKVGYGVYTKARQNAITGKLMPAAPGGSAAVMIE
ALERLKVDYRLAGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Nucleotide

• Length: 396 bp

>AT179121 NZ_CP084578:111253-111498 [Sulfurimonas sp. SWIR-19]
ATGAAAGCTGAAGAATTTGATAAAATATTTGATGATAATGAAGAAGATATCATTGATTATCTTGATATGTCAACAATAAG
AAGACCAAACTTGGAACCAAAAAGAATTAATATTGATTTTCCTGCTTGGATGGTGAAAAAACTTGATGAAGAAGCAAAAC
ATATTGGTGTGAGCCGTCAGGCTATAATAAAAACTTGGCTAGCTGACAAGATTATGCAAATTGAGCATCATAAAGTAGCT
GTATAA

Structures

Toxin

• AlphaFold DB: A0A483NH02

Antitoxin

• AlphaFold DB: A0A1W6B2R8