Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2820455..2821101 Replicon chromosome
Accession NZ_CP063865
Organism Klebsiella pneumoniae strain S130-1

Toxin (Protein)


Gene name higB Uniprot ID A0A483JFR4
Locus tag IOD48_RS14200 Protein ID WP_004188313.1
Coordinates 2820754..2821101 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A483GM64
Locus tag IOD48_RS14195 Protein ID WP_004188315.1
Coordinates 2820455..2820754 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD48_RS14175 2816661..2817419 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
IOD48_RS14180 2817469..2818299 - 831 WP_004188317.1 rhomboid family intramembrane serine protease GlpG -
IOD48_RS14185 2818350..2818679 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
IOD48_RS14190 2818884..2820392 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
IOD48_RS14195 2820455..2820754 - 300 WP_004188315.1 XRE family transcriptional regulator Antitoxin
IOD48_RS14200 2820754..2821101 - 348 WP_004188313.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IOD48_RS14205 2821277..2823724 - 2448 WP_117032111.1 glycogen phosphorylase -
IOD48_RS14210 2823742..2825175 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-78)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13548.57 Da        Isoelectric Point: 6.2327

>T179060 WP_004188313.1 NZ_CP063865:c2821101-2820754 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T179060 NZ_CP084528:1423004-1423300 [Kaistella sp. GW4-15]
ATGATTTTTGAAATAAGTGAAAAAGCAAATGAAGATCTTGAAAACATTTGGTTATACACTTATGAAAATTGGTCCCAAGA
ACAGGCAGACCGCTATTATAATCTTATCCTAAATGAGATTGAATATATTACTGAGAATTTCGAAAGTGGCAAATCATTCG
AACATATTAGAAAAGGTTATCGCTCTGCAAAAGTAAAATCCCATCTTGTTTTTTACCGAATATCAAAAAGAGATACCATA
GAAATCATCAGAATACTTCATCAAAGAATGGATATTGAAAACCGCCTGGTAGAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10873.64 Da        Isoelectric Point: 10.1464

>AT179060 WP_004188315.1 NZ_CP063865:c2820754-2820455 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAAWG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT179060 NZ_CP084528:1422759-1423007 [Kaistella sp. GW4-15]
ATGGGAAAAAATACATCAATATTACTTGGCGATCATTTTGAAAATTTTGTCAACGAAAAAATTACTAGCGGAAAATTTTC
ATCTGTAAGTGAAGTCATTAGAAATGCGTTGCGTTTAATGGAAAATGAAGAAAATAAAACGAAGATTTTGATCAACGAAC
TTAAAATTGGAGAAAAAAGTGGAATCGTAAAAGATTTTGACAGGAATGAAAATTTAAAAAAGATTCACGCCAAACACCTC
GTTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483JFR4

Antitoxin

Source ID Structure
AlphaFold DB A0A483GM64

References