Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 198695..200283 Replicon chromosome
Accession NZ_CP063858
Organism Klebsiella pneumoniae strain M1026-3Ar

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IOD46_RS01005 Protein ID WP_064151580.1
Coordinates 198961..200283 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IOD46_RS01000 Protein ID WP_004176198.1
Coordinates 198695..198961 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IOD46_RS00975 193845..194768 + 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -
IOD46_RS00980 194749..195903 - 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
IOD46_RS00985 196249..197628 + 1380 WP_004184021.1 purine permease -
IOD46_RS00990 197606..198106 + 501 WP_064151579.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
IOD46_RS00995 198103..198429 + 327 WP_004176200.1 hydroxyisourate hydrolase -
IOD46_RS01000 198695..198961 + 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
IOD46_RS01005 198961..200283 + 1323 WP_064151580.1 type II toxin-antitoxin system HipA family toxin Toxin
IOD46_RS01010 200300..201592 - 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
IOD46_RS01015 201734..202738 - 1005 WP_064151581.1 type 1 fimbrial protein -
IOD46_RS01020 202726..205227 - 2502 WP_064151582.1 fimbrial biogenesis outer membrane usher protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T179005 WP_064151580.1 NZ_CP063858:198961-200283 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T179005 NZ_CP084495:c41142-40867 [Klebsiella pneumoniae]
ATGACCACAAGGACGATTGAATACTCAGGCCAGTTCCAGAAAGATGTGAAGAAGGCTCAGAAGCGTCATAAAGACATGAG
CAAGCTTAAAGCCCTTATGACGCTGTTAATCAATGATGCCTTGCCATTGCCTCAAGTCTACAAAGATCACCCTCTACAGG
GGAACTACAAAGGCTATAGGGATGCTCACATAGAACCGGACTGGCTACTCATCTACAAGATAACTGATGAAGTCCTACGC
TTTGAGCGAACCGGAACACATTCAGACCTGTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT179005 WP_004176198.1 NZ_CP063858:198695-198961 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT179005 NZ_CP084495:c41406-41146 [Klebsiella pneumoniae]
ATGGCCGCAAATGCATTTGTTCGTGCTCGTATAGATGAAACACTGAAAAATGAAGCTGCAGTAGTGCTTGCCGGAATGGG
CTTAACCGTTTCCGATCTGGTTCGTATCACTCTGACTAAGGTAGCCAAAGAAAAGGCTCTGCCGTTCGATATGCGTGTTC
CTAACGAGCTTACTGCTAATACCATCGCTAACAGTGAGAAAGGCGTAGACGTTCATACAGCTAAAGATGCTGATGATCTG
TTTAATCAGCTTGGTATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References