Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1051457..1052061 Replicon chromosome
Accession NZ_CP063845
Organism Gloeobacter morelensis MG652769

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag ISF26_RS05165 Protein ID WP_230842855.1
Coordinates 1051726..1052061 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag ISF26_RS05160 Protein ID WP_230842854.1
Coordinates 1051457..1051732 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ISF26_RS05145 (ISF26_05110) 1047076..1047393 + 318 WP_230842851.1 hypothetical protein -
ISF26_RS05150 (ISF26_05115) 1047405..1048793 + 1389 WP_230842852.1 aminopeptidase P family protein -
ISF26_RS05155 (ISF26_05120) 1049202..1051361 + 2160 WP_230842853.1 caspase family protein -
ISF26_RS05160 (ISF26_05125) 1051457..1051732 + 276 WP_230842854.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ISF26_RS05165 (ISF26_05130) 1051726..1052061 + 336 WP_230842855.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
ISF26_RS05170 (ISF26_05135) 1052204..1053343 + 1140 WP_230842856.1 transposase -
ISF26_RS05175 (ISF26_05140) 1053360..1053830 - 471 WP_230842857.1 Clp protease N-terminal domain-containing protein -
ISF26_RS05180 (ISF26_05145) 1053852..1054601 - 750 WP_230842858.1 Uma2 family endonuclease -
ISF26_RS05185 (ISF26_05150) 1054706..1055179 - 474 WP_230842859.1 hypothetical protein -
ISF26_RS05190 (ISF26_05155) 1055267..1057000 + 1734 WP_265745180.1 ABC-F family ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-109)

Antitoxin

SpoVT-AbrB domain

(19-61)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12571.66 Da        Isoelectric Point: 7.8577

>T178948 WP_230842855.1 NZ_CP063845:1051726-1052061 [Gloeobacter morelensis MG652769]
MVEYVPQRGEFIWLSFDPQAGHEQLGVRPALVVSHTLFNERLGFVFVCPVSNTRRKNAFYVLIPEGQAVTGVIMADQLRS
LDYRARRAAAIGLCPEELLSEVLRKIQPILF

Download         Length: 336 bp

>T178948 NZ_CP084433:c1122792-1122589 [Edwardsiella piscicida]
ATGACCAAGATCGATTATCTGATGAAGCTGCGTAAATGCACGACGCTGGATACTCTAGAACGCGTGATCGAAAAGAATAA
ATACGAACTTTCAGATGATGAATTAGAAATTTTTTATTCTGCCGCAGATCATCGTCTGGCCGAATTAACTATGAATAAGC
TATACGACAAAATTCCAGCAGAAGTCTGGCAATACGTCCGCTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10224.73 Da        Isoelectric Point: 4.2939

>AT178948 WP_230842854.1 NZ_CP063845:1051457-1051732 [Gloeobacter morelensis MG652769]
MDILMPSVWEESLKSQVARWGNSLAFRIPKQIAIQLDLKPSTTLVCSVEAGALVVRPVREVKEYSLEELLTGPTEVEDEV
DWGKPEGKEAW

Download         Length: 276 bp

>AT178948 NZ_CP084433:c1123181-1122813 [Edwardsiella piscicida]
ATGGATGAGTACACTTCTTATCAGCATGACATCGCAGAGTTAAAATACCTGTGTGATTCTCTGTATCATCAGGGAATAGA
TGTCCTGGGAGAGAGCCATCACGGCTGGGTCAGCGACCCGACGGCAAAGGTAAATCTACAGCTTAATGAGCTGATTGAGC
ATATTGCCAGCGTCGCGCAATCATTTAAGATCAAATATCCGCATCATTCGGATTTAGCCGAAATATTGGATGATTATCTG
GATGAAACCTATGCCCTGTTTGGCGCCTATAGCGTCAGTGAAACGGCGCTCCGGCACTGGCTGCGCACCAAGCGGCGGGT
GGCATACTGCCTGGCGCATGAAAAGCGCAACGCTGCCTTACATGTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References