Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 776700..777531 Replicon chromosome
Accession NZ_CP063774
Organism Escherichia coli O25b:H4-ST131

Toxin (Protein)


Gene name yeeV Uniprot ID A0A066T988
Locus tag INT78_RS03885 Protein ID WP_000854815.1
Coordinates 777157..777531 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A061Y7A8
Locus tag INT78_RS03880 Protein ID WP_001280918.1
Coordinates 776700..777068 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
INT78_RS03835 771789..772535 + 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -
INT78_RS03840 772618..772968 + 351 Protein_756 hypothetical protein -
INT78_RS03845 772984..773394 + 411 WP_000846703.1 hypothetical protein -
INT78_RS03850 773615..774433 + 819 WP_001542275.1 DUF945 domain-containing protein -
INT78_RS03855 774433..774678 + 246 WP_001164966.1 hypothetical protein -
INT78_RS03860 774772..775245 + 474 WP_001542276.1 antirestriction protein -
INT78_RS03865 775261..775737 + 477 WP_001186200.1 RadC family protein -
INT78_RS03870 775800..776021 + 222 WP_000692345.1 DUF987 domain-containing protein -
INT78_RS03875 776040..776684 + 645 WP_000086752.1 hypothetical protein -
INT78_RS03880 776700..777068 + 369 WP_001280918.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
INT78_RS03885 777157..777531 + 375 WP_000854815.1 type IV toxin-antitoxin system toxin CbtA Toxin
INT78_RS03890 777528..777722 + 195 WP_000988600.1 hypothetical protein -
INT78_RS03895 777735..777848 + 114 WP_001161660.1 DUF957 domain-containing protein -
INT78_RS03900 778137..778283 - 147 Protein_768 transposase domain-containing protein -
INT78_RS03905 778337..778519 + 183 WP_001296208.1 hypothetical protein -
INT78_RS03910 778620..778949 - 330 WP_000450409.1 DUF496 family protein -
INT78_RS03915 779121..780179 - 1059 WP_001200889.1 FUSC family protein -
INT78_RS03920 780377..780850 - 474 WP_001105368.1 DNA gyrase inhibitor SbmC -
INT78_RS03925 780969..782135 - 1167 WP_001296209.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13829.83 Da        Isoelectric Point: 7.1326

>T178795 WP_000854815.1 NZ_CP063774:777157-777531 [Escherichia coli O25b:H4-ST131]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTSDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T178795 NZ_CP084296:4088543-4088728 [Providencia alcalifaciens]
TTGAAAAGTTCGGAGCTGATAAATATGTTAGAAAATAATGGATGGAAATTAGAGCGAGTTAAAGGGAGTCATCACCAATT
TTCTCATCCAGACTTTTCAATTGTTATCACAGTCCCGCATCCTCGAAAGGATTTAAAGATAGGCACACTGAATCAAATCC
TTAAAGCGGCTAAACTGAAACATTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13811.70 Da        Isoelectric Point: 6.4767

>AT178795 WP_001280918.1 NZ_CP063774:776700-777068 [Escherichia coli O25b:H4-ST131]
VSDKLHETNYPDDHNDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT178795 NZ_CP084296:4088783-4089199 [Providencia alcalifaciens]
ATGCTATACCCAGCCTTTATTGAAATTGATCATGATGGTAGTGCGAGTGGTTGGTTTCCAGATATTGAAGGTTGTACTTT
TGCTGGCAACAATATTGAAGATGCTTACACTGATGCAAAATCGGCACTCGATGCCCACTTTGAACTATTAAGTGAAAAAG
GGTTTGAAATTCCTGAACCAAAATCTCAGCAAGAGCATCTAAGTTGTGCAAAAGATGAATATCAAAATGGTCTTTGGTTA
TTCGTTGATATCGATATGGATAAATATGATGGTCGTGCAGAAAGAATTAATATTACGCTACCTCATCGCTTACTGCATCG
TATTGATACGCTAGTTAAAGCCAACCCCGAGTATGGAAGCCGTAGTGGATTCATTGCTGCCGCAGCGCGTAAAGAACTCC
AAAAAACCGATCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A066T988

Antitoxin

Source ID Structure
AlphaFold DB A0A061Y7A8

References