Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1829713..1830406 Replicon chromosome
Accession NZ_CP063511
Organism Escherichia coli strain EH08-18-36

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag IQS18_RS08850 Protein ID WP_000415584.1
Coordinates 1829713..1830009 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag IQS18_RS08855 Protein ID WP_000650107.1
Coordinates 1830011..1830406 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS18_RS08815 1824801..1825115 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
IQS18_RS08820 1825146..1825727 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
IQS18_RS08825 1826046..1826378 + 333 WP_000917684.1 DUF2645 family protein -
IQS18_RS08830 1826424..1827773 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
IQS18_RS08835 1827770..1828429 - 660 WP_001221493.1 two-component system response regulator QseB -
IQS18_RS08840 1828581..1828973 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
IQS18_RS08845 1829026..1829508 + 483 WP_000183505.1 transcriptional regulator -
IQS18_RS08850 1829713..1830009 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
IQS18_RS08855 1830011..1830406 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
IQS18_RS08860 1830539..1832146 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
IQS18_RS08865 1832284..1834542 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T178579 WP_000415584.1 NZ_CP063511:1829713-1830009 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T178579 NZ_CP084164:c267150-266860 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT178579 WP_000650107.1 NZ_CP063511:1830011-1830406 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT178579 NZ_CP084164:c267461-267147 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References