Detailed information of TA system TA178476

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1455089..1455347
• Replicon: chromosome
• Accession: NZ_CP063492
• Organism: Escherichia coli strain EF5-18-41

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: IQS14_RS06940
• Protein ID: WP_000809168.1
• Coordinates: 1455089..1455241 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1455290..1455347 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IQS14_RS06920	1450331..1451044	-	714	WP_001102367.1	acidic protein MsyB	-
IQS14_RS06925	1451070..1451474	-	405	WP_000843584.1	DUF2541 family protein	-
IQS14_RS06930	1451850..1453766	+	1917	WP_000516135.1	molecular chaperone DnaK	-
IQS14_RS06935	1453855..1454985	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
IQS14_RS06940	1455089..1455241	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	1455290..1455347	+	58	-	-	Antitoxin
IQS14_RS06945	1455827..1456993	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
IQS14_RS06950	1457059..1457958	+	900	WP_001300855.1	transcriptional activator NhaR	-
IQS14_RS06955	1457996..1458955	-	960	WP_000871674.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T178476 WP_000809168.1 NZ_CP063492:c1455241-1455089 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T178476 NZ_CP084032:462518-463852 [Pectobacterium colocasium]
ATGCCTCGAACACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGACCCGAGGCGAAGA
TAAGTTGCAATATCTTCCCGAATGGATCGCTGATGAACAGGGAAGACCTTTATCACTTTCTTTGCTTTTCACCCCCGGTA
ATCAGCTTTGGCGTGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCAACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGGAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAAGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCACTTTGTGAAGCTGAGATCGCCACTA
TATTGCGTAATACAACAGCGGCATTGCTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAAGGCAATGGTGTTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTGTGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTTGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAAGTATTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCGGGGATTTCCGATATTATGACCATACTGAGTCATTCGGAACAGGCTGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCGCTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGTAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGTAGACGACAGGTTGAAGCCATGATGGATGATATT
ATATCTAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCCCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT178476 NZ_CP063492:1455290-1455347 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin