Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4757246..4758081 Replicon chromosome
Accession NZ_CP063483
Organism Escherichia coli strain EM03-18-08

Toxin (Protein)


Gene name yeeV Uniprot ID B1LDL9
Locus tag IQS21_RS22780 Protein ID WP_001094444.1
Coordinates 4757246..4757623 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag IQS21_RS22785 Protein ID WP_001285607.1
Coordinates 4757713..4758081 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS21_RS22760 4752709..4755825 + 3117 WP_000149665.1 HsdR family type I site-specific deoxyribonuclease -
IQS21_RS22765 4756313..4756459 - 147 WP_001290178.1 hypothetical protein -
IQS21_RS22770 4756544..4756741 - 198 WP_001327226.1 DUF957 domain-containing protein -
IQS21_RS22775 4756761..4757249 - 489 WP_000761685.1 hypothetical protein -
IQS21_RS22780 4757246..4757623 - 378 WP_001094444.1 TA system toxin CbtA family protein Toxin
IQS21_RS22785 4757713..4758081 - 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS21_RS22790 4758161..4758382 - 222 WP_000692350.1 DUF987 domain-containing protein -
IQS21_RS22795 4758469..4758945 - 477 WP_001384029.1 RadC family protein -
IQS21_RS22800 4758960..4759445 - 486 WP_000213722.1 antirestriction protein -
IQS21_RS22805 4759537..4760355 - 819 WP_001175175.1 DUF945 domain-containing protein -
IQS21_RS22810 4760445..4760654 - 210 WP_032150870.1 DUF905 family protein -
IQS21_RS22815 4760684..4761361 - 678 WP_001097301.1 hypothetical protein -
IQS21_RS22820 4761481..4762365 - 885 WP_000010408.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4735345..4765910 30565


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14087.02 Da        Isoelectric Point: 7.3523

>T178435 WP_001094444.1 NZ_CP063483:c4757623-4757246 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SVCTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T178435 NZ_CP084023:4265839-4266090 [Pectobacterium aroidearum]
ATGCGTACAATTAGCTACAGTGAAGCCCGACAAAATCTATCGGCGACCATGATGAAAACGGTCGAAGACCGTGCTCCCAT
TCTTATCACTCGACAGAATGGTGAAGCCTGCGTGCTCATGTCTTTGGAAGAATATAACTCTCTAGAGGAGACCGCGTATT
TACTGCGTTCACCAGCAAATGCAAAAAGACTGATGAACTCAATCGAGAGCCTTAAAGCTGGCAATGGCGAAGAAAGAGAT
ATCATTGAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT178435 WP_001285607.1 NZ_CP063483:c4758081-4757713 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT178435 NZ_CP084023:4266087-4266341 [Pectobacterium aroidearum]
GTGAAGCTAATCTGGTCAGAAGAAGCATGGGAAGACTACCTGTACTGGCAGGACATCGATAAGCGGATGGTCAAAAAAAT
CAATGAATTAATAAAAGAAACGCGCAGAACACCTTTTGAGGGAAAAGGAAAACCAGAGCCACTTAAACATAATCTTGCTG
GTTTCTGGTCGCGCCGTATCACCGAAGAACATCGTCTGGTTTATGCCATCACCGATGACGCCATGATGATCGCAGCCTGC
CGCTACCACTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1LDL9

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References