Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 721294..722092 Replicon chromosome
Accession NZ_CP063483
Organism Escherichia coli strain EM03-18-08

Toxin (Protein)


Gene name yeeV Uniprot ID U9XMP3
Locus tag IQS21_RS03360 Protein ID WP_000854735.1
Coordinates 721294..721671 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A067H947
Locus tag IQS21_RS03365 Protein ID WP_001285415.1
Coordinates 721718..722092 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IQS21_RS03335 716641..717564 - 924 WP_000535961.1 carboxylate/amino acid/amine transporter -
IQS21_RS03340 717675..718859 - 1185 WP_001172876.1 sugar efflux transporter -
IQS21_RS03345 719655..720497 - 843 WP_000036706.1 DUF4942 domain-containing protein -
IQS21_RS03350 720594..720791 - 198 WP_000839266.1 DUF957 domain-containing protein -
IQS21_RS03355 720809..721297 - 489 WP_000761680.1 hypothetical protein -
IQS21_RS03360 721294..721671 - 378 WP_000854735.1 TA system toxin CbtA family protein Toxin
IQS21_RS03365 721718..722092 - 375 WP_001285415.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IQS21_RS03370 722172..722393 - 222 WP_000692309.1 DUF987 domain-containing protein -
IQS21_RS03375 722456..722932 - 477 WP_001366830.1 RadC family protein -
IQS21_RS03380 722948..723427 - 480 WP_072649143.1 antirestriction protein -
IQS21_RS03385 723509..724327 - 819 WP_205561415.1 DUF932 domain-containing protein -
IQS21_RS03390 724417..724650 - 234 WP_001278287.1 DUF905 family protein -
IQS21_RS03395 724656..725333 - 678 WP_001097368.1 hypothetical protein -
IQS21_RS03400 725452..726336 - 885 WP_000010392.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14061.07 Da        Isoelectric Point: 8.2904

>T178412 WP_000854735.1 NZ_CP063483:c721671-721294 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T178412 NZ_CP084007:193347-193685 [Flavonifractor plautii]
ATGGTGATGATTTTTGAGCAGGGGGACATCGTCTATCTGGACTTTGATCCCCAGTCCGGCCATGAGCAGAAGAGCCGCCG
TCCTGCCTTGGTGATCAGCAACAACCTGTTCAACCGGGTCAGCAGCCTGACCATGGTTTGCCCCATCACCCATACAGACC
GGGGCCACCCGTTCCACCTCCGGCTGGATGAGCGCACCAGGACGGACGGGGTCATCCTGTGTGATCAGGCCCGGATGCTG
GATCTGAACAGCCGCCATGCCTCCTTTGTGGAGCGCGCTCCGGAGGATATCTCCGCAGAGGCGGTAGATATGGTCATCGG
ATTCCTGGAGCCGAAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13663.32 Da        Isoelectric Point: 5.8640

>AT178412 WP_001285415.1 NZ_CP063483:c722092-721718 [Escherichia coli]
VSDTHPGTTHPDNNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT178412 NZ_CP084007:193087-193353 [Flavonifractor plautii]
ATGTATGCGACAATCCAAAAATGGGGCAACAGCCAGGGGCTGCGAATCCCCAAGGCGCTCCTGGACGCGGTTGGCCTGAA
GGAGCACGATCGGGTGGAGCTGGTGCAGATGGATGATGGCATCAACATCCGGCGTGCCTCTGCCACCCCGCACCGCACCC
TGGAGGAGCGCCTCATTGCGTTCTACGGAAAGCCCATTGACCAGATCGGCCGGATAGAGGGTGAAGAACTGGACTGGGGG
AAAGCGGAGGGCTCTGAGGCATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XMP3

Antitoxin

Source ID Structure
AlphaFold DB A0A067H947

References