Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3135899..3137156 Replicon chromosome
Accession NZ_CP063455
Organism Pseudomonas protegens strain PC-578039

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IP586_RS14585 Protein ID WP_267269939.1
Coordinates 3136584..3137156 (+) Length 191 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IP586_RS14580 Protein ID WP_267270038.1
Coordinates 3135899..3136456 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IP586_RS14550 3131094..3131375 - 282 WP_267269936.1 type II toxin-antitoxin system ParD family antitoxin -
IP586_RS14555 3131484..3132104 - 621 WP_110597006.1 LysE family translocator -
IP586_RS14560 3132345..3132932 - 588 WP_102879701.1 AidA/PixA family protein -
IP586_RS14565 3133184..3133798 - 615 WP_267269937.1 alpha/beta fold hydrolase -
IP586_RS14570 3134032..3135228 + 1197 WP_267269938.1 PrpF domain-containing protein -
IP586_RS14575 3135368..3135709 - 342 WP_110653544.1 low molecular weight protein tyrosine phosphatase family protein -
IP586_RS14580 3135899..3136456 + 558 WP_267270038.1 helix-turn-helix transcriptional regulator Antitoxin
IP586_RS14585 3136584..3137156 + 573 WP_267269939.1 HD domain-containing protein Toxin
IP586_RS14590 3137411..3139591 + 2181 WP_267269940.1 catalase/peroxidase HPI -
IP586_RS14595 3139719..3140147 - 429 WP_011060992.1 hypothetical protein -
IP586_RS14600 3140375..3140638 + 264 WP_123577621.1 hypothetical protein -
IP586_RS14605 3140641..3140829 + 189 WP_267269941.1 DUF6360 family protein -
IP586_RS14610 3140876..3141544 - 669 WP_267270039.1 phytanoyl-CoA dioxygenase family protein -
IP586_RS14615 3141835..3142122 + 288 WP_267269942.1 DUF3077 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-179)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-46)


Sequences

Toxin        


Download         Length: 191 a.a.        Molecular weight: 21584.24 Da        Isoelectric Point: 5.1035

>T178264 WP_267269939.1 NZ_CP063455:3136584-3137156 [Pseudomonas protegens]
MTPELLSGRLEFLREAEKLKDVLRSAYTSSGRQESTAEHSWRLCLMALLFEDQLGELDLLRVLKLCIVHDLGEAIHGDIP
AVAQAGHPHKSQQERDDLQFLARSLDAPARQRLLDLWDEYEGAASAEAQTVKALDKLETLLQHNQGQNPADFDYRFNLGY
GRRYTDASPLFQALRQQIDIDTQRRLNAQG

Download         Length: 573 bp

>T178264 NZ_CP083888:4092558-4092815 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20371.23 Da        Isoelectric Point: 7.0307

>AT178264 WP_267270038.1 NZ_CP063455:3135899-3136456 [Pseudomonas protegens]
MSVALFTSPHLGLALRRWRLLHRVKQQHAAELFGVAQSSISRWENGQQAMEPAERARLEQLLAANLSAAADQALARLVND
SPRAVHLVCDLTHRLLACSATRAGQFGVPLSELLGQSLWGFCTEEITRKEAALDDLGWREVLSPPSVEFFSGHNDSAIVP
IAPSQCRWTRLNLSDGNAVRLVETL

Download         Length: 558 bp

>AT178264 NZ_CP083888:4092827-4093372 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References