Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-pasA/RelE-HTH
Location 760109..760577 Replicon chromosome
Accession NZ_CP063418
Organism Actinomyces sp. ZJ34

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HRL51_RS03085 Protein ID WP_172193334.1
Coordinates 760320..760577 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag HRL51_RS03080 Protein ID WP_172193333.1
Coordinates 760109..760336 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HRL51_RS03045 755973..756236 + 264 WP_172193325.1 hypothetical protein -
HRL51_RS03050 756323..756730 + 408 WP_172193327.1 DNA-processing protein DprA -
HRL51_RS03055 756699..757478 + 780 WP_172119571.1 DUF3800 domain-containing protein -
HRL51_RS03060 757778..758074 - 297 WP_172119570.1 type II toxin-antitoxin system YafQ family toxin -
HRL51_RS03065 758074..758337 - 264 WP_172193329.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
HRL51_RS03070 758469..759512 - 1044 WP_172193386.1 lytic transglycosylase domain-containing protein -
HRL51_RS03075 759548..759916 - 369 WP_172193331.1 hypothetical protein -
HRL51_RS03080 760109..760336 + 228 WP_172193333.1 ribbon-helix-helix protein, CopG family Antitoxin
HRL51_RS03085 760320..760577 + 258 WP_172193334.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HRL51_RS03090 760698..760907 - 210 WP_172193336.1 hypothetical protein -
HRL51_RS03095 762212..763039 - 828 WP_172193338.1 tyrosine-type recombinase/integrase -
HRL51_RS03100 763174..763569 - 396 WP_172121340.1 hypothetical protein -
HRL51_RS03105 763572..764339 - 768 WP_172193340.1 AAA family ATPase -
HRL51_RS03110 764410..764787 - 378 WP_172193342.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9784.27 Da        Isoelectric Point: 9.8683

>T178177 WP_172193334.1 NZ_CP063418:760320-760577 [Actinomyces sp. ZJ34]
MAWTIEVADSAVKALRKIDPQVRRRIWSTVREVAELEDPRSRGKALTADLRGLWCYRAGDWRIICDIDDGRVVVVEVGRR
SRVYG

Download         Length: 258 bp

>T178177 NZ_CP083872:c4226643-4226470 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8848.00 Da        Isoelectric Point: 5.7065

>AT178177 WP_172193333.1 NZ_CP063418:760109-760336 [Actinomyces sp. ZJ34]
MVTSIRLDPQIERRYEALARHTHRSKSFYLRQAIEQAIDRMEFEYRVLSAVEDVRAGRMKTYSLDEAETLIGVDD

Download         Length: 228 bp

>AT178177 NZ_CP083872:c4226967-4226671 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References