Detailed information of TA system TA177900

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ataT-tacA/GNAT-DUF1778
• Location: 1159580..1160343
• Replicon: chromosome
• Accession: NZ_CP063320
• Organism: Mycobacteroides abscessus subsp. abscessus strain GD25

Toxin (Protein)

• Gene name: ataT
• Uniprot ID: U5X3E3
• Locus tag: IN840_RS05690
• Protein ID: WP_023363547.1
• Coordinates: 1159580..1160077 (-)
• Length: 166 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: -
• Locus tag: IN840_RS05695
• Protein ID: WP_053082894.1
• Coordinates: 1160074..1160343 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IN840_RS05670	1156191..1156823	+	633	WP_023363553.1	class I SAM-dependent methyltransferase	-
IN840_RS05675	1157013..1157609	-	597	WP_023363551.1	ABATE domain-containing protein	-
IN840_RS05680	1157710..1158279	+	570	WP_023363549.1	TIGR03086 family protein	-
IN840_RS05685	1158315..1159184	+	870	WP_052622775.1	pyridoxamine 5'-phosphate oxidase family protein	-
IN840_RS05690	1159580..1160077	-	498	WP_023363547.1	GNAT family N-acetyltransferase	Toxin
IN840_RS05695	1160074..1160343	-	270	WP_053082894.1	DUF1778 domain-containing protein	Antitoxin
IN840_RS05700	1160795..1161268	+	474	WP_005082966.1	MarR family transcriptional regulator	-
IN840_RS05705	1161276..1162691	+	1416	WP_005113402.1	membrane protein	-
IN840_RS05710	1162696..1163790	-	1095	WP_025089030.1	DUF2236 domain-containing protein	-
IN840_RS05715	1163877..1164479	+	603	WP_005113405.1	TetR/AcrR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (43-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (9-82)

Sequences

Toxin

Protein

• Length: 166 a.a.
• Molecular weight: 18258.94 Da
• Isoelectric Point: 9.5209

>T177900 WP_023363547.1 NZ_CP063320:c1160077-1159580 [Mycobacteroides abscessus subsp. abscessus]
VSYEGPVLFGADHIVDDFDCGNDVLNEWLRTKALHNQREGGSRTWVVLDGRRVVAFYASSTAVLMRSRATKRAARNQPDP
LPAVLLGRLAVDANHQGRGLAAALLKHFILKSLEVAELTGVRLLLVHANNDTARRFYLRYGFEPSPVDDLTLMLLVKDVR
PSPSA

Nucleotide

• Length: 498 bp

>T177900 NZ_CP083754:13833-14141 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCCCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9925.25 Da
• Isoelectric Point: 5.6845

>AT177900 WP_053082894.1 NZ_CP063320:c1160343-1160074 [Mycobacteroides abscessus subsp. abscessus]
VETKSGRWHLRVTAAQDAVVRRVLDVTGESLNDYVVRHAVQAAEADLADRRVFVLDDAAWTDLQALLDRPPSPKPELARL
LANPSILER

Nucleotide

• Length: 270 bp

>AT177900 NZ_CP083754:13594-13830 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACGGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACTTTTTAA

Structures

Toxin

• AlphaFold DB: A0A8B4DM98