Detailed information of TA system TA177722

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3959630..3960465
• Replicon: chromosome
• Accession: NZ_CP063214
• Organism: Escherichia coli strain ERP001

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: IL987_RS19100
• Protein ID: WP_193579204.1
• Coordinates: 3960088..3960465 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: IL987_RS19095
• Protein ID: WP_193579203.1
• Coordinates: 3959630..3959998 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IL987_RS19055	3954905..3955585	+	681	WP_001282920.1	WYL domain-containing protein	-
IL987_RS19060	3955733..3956410	+	678	WP_001519094.1	hypothetical protein	-
IL987_RS19065	3956416..3956649	+	234	WP_021545393.1	DUF905 family protein	-
IL987_RS19070	3956748..3957566	+	819	WP_193579202.1	DUF945 domain-containing protein	-
IL987_RS19075	3957658..3958143	+	486	WP_193579182.1	antirestriction protein	-
IL987_RS19080	3958159..3958627	+	469	Protein_3725	RadC family protein	-
IL987_RS19085	3958696..3958917	+	222	WP_000692323.1	DUF987 domain-containing protein	-
IL987_RS19090	3958936..3959580	+	645	WP_021574214.1	hypothetical protein	-
IL987_RS19095	3959630..3959998	+	369	WP_193579203.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IL987_RS19100	3960088..3960465	+	378	WP_193579204.1	TA system toxin CbtA family protein	Toxin
IL987_RS19105	3960462..3960950	+	489	WP_021574216.1	hypothetical protein	-
IL987_RS19110	3960962..3961159	+	198	WP_000839272.1	DUF957 domain-containing protein	-
IL987_RS19115	3961238..3961396	+	159	WP_170990682.1	hypothetical protein	-
IL987_RS19120	3962349..3964385	+	2037	WP_193579205.1	hypothetical protein	-
IL987_RS19125	3964784..3964963	-	180	WP_001298063.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimB / fimE / fimA / fimI / fimC	3948612..3974515	25903

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14216.18 Da
• Isoelectric Point: 7.2920

>T177722 WP_193579204.1 NZ_CP063214:3960088-3960465 [Escherichia coli]
MKTLPDTHVRAASRCPPPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEADISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Nucleotide

• Length: 378 bp

>T177722 NZ_CP083638:4325280-4325567 [Escherichia fergusonii]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGATGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13556.27 Da
• Isoelectric Point: 5.9520

>AT177722 WP_193579203.1 NZ_CP063214:3959630-3959998 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCIGARLVQEGNRLHYLADRADIRGRFSDADAYYLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYIAIYPTPGTKT

Nucleotide

• Length: 369 bp

>AT177722 NZ_CP083638:4325554-4325856 [Escherichia fergusonii]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
CAAATCCGACGAGGATATTGATTACAGCGACATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAATAAAAAATAA