Detailed information of TA system TA177697

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/PHD-RelE
• Location: 2310533..2311053
• Replicon: chromosome
• Accession: NZ_CP063212
• Organism: Trueperella sp. 19M2397 strain 19OD0592

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: INS90_RS10750
• Protein ID: WP_197553103.1
• Coordinates: 2310793..2311053 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: INS90_RS10745
• Protein ID: WP_193326696.1
• Coordinates: 2310533..2310796 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INS90_RS10720	2305563..2306264	+	702	WP_197553093.1	type I-E CRISPR-associated protein Cas5/CasD	-
INS90_RS10725	2306560..2308311	-	1752	WP_197553095.1	putative DNA binding domain-containing protein	-
INS90_RS10730	2308335..2308565	-	231	WP_197553097.1	hypothetical protein	-
INS90_RS10735	2308564..2309088	+	525	WP_197553099.1	lipocalin family protein	-
INS90_RS10740	2309171..2310433	-	1263	WP_197553101.1	methyltransferase domain-containing protein	-
INS90_RS10745	2310533..2310796	+	264	WP_193326696.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
INS90_RS10750	2310793..2311053	+	261	WP_197553103.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
INS90_RS10755	2311058..2313721	-	2664	WP_197555360.1	ATP-dependent helicase HrpB	-
INS90_RS10760	2313718..2314338	-	621	WP_197553105.1	TetR/AcrR family transcriptional regulator	-
INS90_RS10765	2314460..2315137	-	678	WP_197553107.1	TrkA family potassium uptake protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (7-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9930.41 Da
• Isoelectric Point: 10.3588

>T177697 WP_197553103.1 NZ_CP063212:2310793-2311053 [Trueperella sp. 19M2397]
VNYRVELTTAAAREIKKLPHEARGRILGALEKLADDPRPRGAKKLVGEENAWRIRLGDYRIIYDIFDDTLTVTVVRAGHR
REIYRS

Nucleotide

• Length: 261 bp

>T177697 NZ_CP083631:c3244760-3244605 [Klebsiella quasipneumoniae]
CTGCGTGCAGCGAAGTCATTCCTGTCACCTGCCGCTATCTGGCAAATGTTACTTACCCATCTGCTTGAACAGCACTATGG
TCTAACGCTAAACGATACACCTTTCAGTGATGAAACCGTTACACAGGAACATTTCACTATAGGTATCCATCTCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9524.68 Da
• Isoelectric Point: 4.6412

>AT177697 WP_193326696.1 NZ_CP063212:2310533-2310796 [Trueperella sp. 19M2397]
MNTITSEVSTRELRSQLSDVLGRAMYAGERIGVTRHGKLAAVVVSVADLEALEEFEMAQDVAAYRAARAEDDGGRVSLDE
LRRTLTQ

Nucleotide

• Length: 264 bp

>AT177697 NZ_CP083631:c3245161-3244805 [Klebsiella quasipneumoniae]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCCCCCCTGCAAACAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCGACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAATGGTGCTTTCA
GCGACGAGCATGTGTTGCGCCTCGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGCTGATGCTCACCAGCGGAGAA
CTCTCTCCCCGCCATCAGCACTGTGTCACCCTCTATCACAACGGACTCATCTGCGACGCCGATACGCTTGGTAGTTGTGG
TTACGTATACATCGCTGTTTATCCCACTCAACGTTAA