Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4459475..4460070 Replicon chromosome
Accession NZ_CP063047
Organism Pseudomonas aeruginosa strain KC-Tt-1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag IL983_RS20525 Protein ID WP_003113526.1
Coordinates 4459792..4460070 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag IL983_RS20520 Protein ID WP_003111575.1
Coordinates 4459475..4459780 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IL983_RS20490 4454642..4455076 - 435 WP_121379848.1 DNA-binding protein -
IL983_RS20495 4455614..4455904 - 291 WP_049295997.1 DUF5447 family protein -
IL983_RS20500 4456116..4456388 - 273 WP_003115921.1 hypothetical protein -
IL983_RS20505 4456835..4457170 + 336 WP_029528819.1 hypothetical protein -
IL983_RS20510 4457216..4458130 - 915 WP_071538325.1 sce7725 family protein -
IL983_RS20515 4458091..4458978 - 888 WP_124989691.1 sce7726 family protein -
IL983_RS20520 4459475..4459780 - 306 WP_003111575.1 HigA family addiction module antidote protein Antitoxin
IL983_RS20525 4459792..4460070 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IL983_RS20530 4460399..4462627 + 2229 WP_034036795.1 TonB-dependent receptor -
IL983_RS20535 4462698..4463345 - 648 WP_003095021.1 carbonate dehydratase -
IL983_RS20540 4463407..4464645 - 1239 WP_034036794.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T177565 WP_003113526.1 NZ_CP063047:c4460070-4459792 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T177565 NZ_CP083539:3016179-3016445 [Jannaschia sp. W003]
GTGAAACTGCTCTTCGCTGACGGTGCCTGGGAGGACTACCTCCACTGGCACCGCACCGACCCGAAGCTCCTGCGGCGCAT
CAACGATCTGATTCGCGAGGCGCGCCGGACGCCGTTCGACGGCATCGGCAAGCCCGAGCCGCTGCGCGGCGACCTCTCGG
GCTGGTGGTCGCGCCGCATCACCCGCGAGCACCGCATGGTCTACCGCGTCGCCGGCGAGGGCGACGCCCGGGCGCTGGAG
ATCGCCCAGCTCCGCTACCACTACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT177565 WP_003111575.1 NZ_CP063047:c4459780-4459475 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT177565 NZ_CP083539:3015929-3016198 [Jannaschia sp. W003]
ATGGACATCGTCAGCTACACCGACGCCCGCAAGCACCTGAAGGCCGTCATGGACCGTGCCATCACCGACCGCACCGAGAC
GGTCGTCACCCGCGCAGGCCGCGAGGCCGTGGTGGTGGTCGGCAAGGAGGAGTGGGACGCCATCCAGACCACGCTCCACC
TCCTGTCCTCGCCCGCGAACGCGGCGCGTCTGCGCGCGGCCGTGGGGCAGCTCGATGCCGGGGGCGGCGCGGAGCGGGAG
CTGATCGACGGTGAAACTGCTCTTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References