Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4138352..4138971 Replicon chromosome
Accession NZ_CP063011
Organism Klebsiella pneumoniae strain CriePir116

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GJI97_RS20455 Protein ID WP_002892050.1
Coordinates 4138753..4138971 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GJI97_RS20450 Protein ID WP_002892066.1
Coordinates 4138352..4138726 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJI97_RS20440 4133504..4134697 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJI97_RS20445 4134720..4137866 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GJI97_RS20450 4138352..4138726 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GJI97_RS20455 4138753..4138971 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GJI97_RS20460 4139130..4139696 + 567 WP_002892030.1 maltose O-acetyltransferase -
GJI97_RS20465 4139668..4139808 - 141 WP_004147370.1 hypothetical protein -
GJI97_RS20470 4139829..4140299 + 471 WP_002892026.1 YlaC family protein -
GJI97_RS20475 4140274..4141725 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
GJI97_RS20480 4141826..4142524 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GJI97_RS20485 4142521..4142661 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GJI97_RS20490 4142661..4142924 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T177494 WP_002892050.1 NZ_CP063011:4138753-4138971 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T177494 NZ_CP083503:c2178486-2178175 [Escherichia coli]
ATGCACATCATTTCGAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTATACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT177494 WP_002892066.1 NZ_CP063011:4138352-4138726 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT177494 NZ_CP083503:c2178178-2177759 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCCGAGTTCGACAAAGCCGTTGCAGCAATGCCGGTT
GGCGTGGCGTTACTTCGTACGCTGATTGATCAACATAATCTGACCTACGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGGCAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGTGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References