Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4630759..4631450 Replicon chromosome
Accession NZ_CP062997
Organism Klebsiella pneumoniae strain CriePir197

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag GJJ12_RS22875 Protein ID WP_009309816.1
Coordinates 4630759..4631100 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag GJJ12_RS22880 Protein ID WP_009309815.1
Coordinates 4631124..4631450 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJJ12_RS22845 4625800..4626555 + 756 Protein_4484 adenosine deaminase -
GJJ12_RS22855 4627874..4628116 + 243 Protein_4486 adenosine deaminase -
GJJ12_RS22860 4628113..4628667 + 555 WP_009309819.1 hypothetical protein -
GJJ12_RS22865 4628667..4629461 + 795 WP_009309818.1 SIR2 family protein -
GJJ12_RS22870 4629809..4630642 - 834 WP_009309817.1 DUF4942 domain-containing protein -
GJJ12_RS22875 4630759..4631100 - 342 WP_009309816.1 TA system toxin CbtA family protein Toxin
GJJ12_RS22880 4631124..4631450 - 327 WP_009309815.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GJJ12_RS22885 4631464..4631865 - 402 Protein_4492 DNA repair protein RadC -
GJJ12_RS22890 4631898..4632866 + 969 WP_074193784.1 IS5 family transposase -
GJJ12_RS22895 4633047..4634264 + 1218 WP_064161712.1 restriction endonuclease subunit S -
GJJ12_RS22900 4634261..4635952 + 1692 WP_064161713.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4603588..4651461 47873
- inside IScluster/Tn - - 4621480..4632866 11386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-109)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12900.84 Da        Isoelectric Point: 8.4982

>T177437 WP_009309816.1 NZ_CP062997:c4631100-4630759 [Klebsiella pneumoniae]
MKTLPATTQRAAKPCPSPVTVWQMLLTRLLEQHYGLSLNDTPFSDETVIQEHINAGITLADAVNFLVEKYELVRIDRRGF
NCQEQSPYLRAVDILRARQATGLLQYRRNTLSL

Download         Length: 342 bp

>T177437 NZ_CP083492:c2526177-2525779 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12292.01 Da        Isoelectric Point: 6.6290

>AT177437 WP_009309815.1 NZ_CP062997:c4631450-4631124 [Klebsiella pneumoniae]
MPLTDAIQWGLKRSFTPNFGARLVQEGNRLHYLADRANITGKFVDVECQKLEEAFPHFIRQMELMLSTGELNPRHAHSVT
LYHNAFTCEADTLGSCGYVYIVIYPTQS

Download         Length: 327 bp

>AT177437 NZ_CP083492:c2526473-2526180 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References