Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-Axe/YoeB-RelB
Location 1140074..1140594 Replicon chromosome
Accession NZ_CP062949
Organism Bifidobacterium longum subsp. longum strain JCM 7050

Toxin (Protein)


Gene name yoeB Uniprot ID A0A4V2N101
Locus tag BL7050_RS04615 Protein ID WP_065436690.1
Coordinates 1140074..1140328 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID A0A4R0SSB9
Locus tag BL7050_RS04620 Protein ID WP_065436689.1
Coordinates 1140328..1140594 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BL7050_RS04590 1135742..1137418 - 1677 WP_117738361.1 ATP-binding protein -
BL7050_RS04595 1137507..1137752 - 246 WP_007053507.1 hypothetical protein -
BL7050_RS04600 1138024..1138542 + 519 WP_065436692.1 hypothetical protein -
BL7050_RS04605 1138553..1138933 + 381 WP_065436691.1 hypothetical protein -
BL7050_RS04610 1139016..1140080 + 1065 WP_193021209.1 hypothetical protein -
BL7050_RS04615 1140074..1140328 - 255 WP_065436690.1 Txe/YoeB family addiction module toxin Toxin
BL7050_RS04620 1140328..1140594 - 267 WP_065436689.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BL7050_RS04625 1140776..1141156 + 381 WP_060868194.1 hypothetical protein -
BL7050_RS04630 1141179..1141601 + 423 WP_131293171.1 hypothetical protein -
BL7050_RS04635 1141665..1142045 + 381 WP_131314107.1 hypothetical protein -
BL7050_RS04640 1142335..1143786 - 1452 WP_131212375.1 hypothetical protein -
BL7050_RS04645 1143956..1144138 - 183 WP_032737828.1 hypothetical protein -
BL7050_RS04650 1144186..1144428 + 243 Protein_894 hypothetical protein -
BL7050_RS04655 1145066..1145494 + 429 Protein_895 secretion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1091853..1186512 94659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-76)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9932.40 Da        Isoelectric Point: 8.4862

>T177353 WP_065436690.1 NZ_CP062949:c1140328-1140074 [Bifidobacterium longum subsp. longum]
MLLCWTEDAWADYLYWQAQDRKTLKRVNTLIRDMQRTPFEGIGKPEPLKWGLSGAWSRRIDSANRIIYTVADDRLCILSA
KDHY

Download         Length: 255 bp

>T177353 NZ_CP083449:44353-44640 [Pantoea eucrina]
ATGGCGTATTTACTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGTTGGCTGAAGTACTTGAGTCACCCCGGATTGAAGCGAACAAGCTCCGTGGTATGCCTGACTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTCTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9908.15 Da        Isoelectric Point: 4.3407

>AT177353 WP_065436689.1 NZ_CP062949:c1140594-1140328 [Bifidobacterium longum subsp. longum]
MTQAVAYSNFRANLKTYMRKVNEDADTLLVTNADPEDNVVVMSADDYDSLMETLRVYQNPYLSDKVMRGMAQVRQGQTMA
HDLIEAGA

Download         Length: 267 bp

>AT177353 NZ_CP083449:44114-44353 [Pantoea eucrina]
ATGGGTAGCATAAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTTACTCC
CTCTGAAGCGCTTCGTCTCATGCTTGAATATATCGCTGAAAATGAACGTTTGCCGTTTAAACAGACACTTCTTAGTGATG
AAGACGCTGAACTCGTGGAGATAGTGAAAGAGCGTCTTCGCAATCCTAAGCCAGTACGCGTGACGCTGGATGAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4V2N101

Antitoxin

Source ID Structure
AlphaFold DB A0A4R0SSB9

References