Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 101636..102164 Replicon chromosome
Accession NZ_CP062946
Organism Thalassotalea sp. LPB0316

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LP316_RS00485 Protein ID WP_193022169.1
Coordinates 101877..102164 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LP316_RS00480 Protein ID WP_193022168.1
Coordinates 101636..101887 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LP316_RS00445 96990..97457 - 468 WP_193022161.1 isoprenylcysteine carboxylmethyltransferase family protein -
LP316_RS00450 97495..98097 - 603 WP_193022162.1 glutathione S-transferase family protein -
LP316_RS00455 98514..98765 + 252 WP_193022163.1 hypothetical protein -
LP316_RS00460 98813..99439 + 627 WP_193022164.1 uracil phosphoribosyltransferase -
LP316_RS00465 99482..99682 - 201 WP_193022165.1 hypothetical protein -
LP316_RS00470 99759..100646 - 888 WP_193022166.1 aspartoacylase -
LP316_RS00475 100916..101365 + 450 WP_193022167.1 hypothetical protein -
LP316_RS00480 101636..101887 + 252 WP_193022168.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LP316_RS00485 101877..102164 + 288 WP_193022169.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LP316_RS00490 102298..106215 - 3918 WP_193023764.1 cobaltochelatase subunit CobN -
LP316_RS00495 106395..106748 - 354 WP_193022170.1 DUF2149 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-70)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11028.08 Da        Isoelectric Point: 10.6351

>T177339 WP_193022169.1 NZ_CP062946:101877-102164 [Thalassotalea sp. LPB0316]
MTYKLKFIPAAKKEWDKLAEPLKTQFKKKLADRLENPHVPSAKLRGYESVYKIKLRTAGYRLAYEVINNEIVVYVLAVGK
RDKNAIYKKLASRSI

Download         Length: 288 bp

>T177339 NZ_CP083445:1361052-1361270 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9230.40 Da        Isoelectric Point: 3.9840

>AT177339 WP_193022168.1 NZ_CP062946:101636-101887 [Thalassotalea sp. LPB0316]
MRQVLADCSASISELKKNPTALLNEADGAAIAILNHNKPAAYLVPAETYEWLMEVVDDYELAKVVEERRQDLSDAIEVNL
DDL

Download         Length: 252 bp

>AT177339 NZ_CP083445:1360651-1361025 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References