Detailed information of TA system TA177336

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 2469880..2470488
• Replicon: chromosome
• Accession: NZ_CP062940
• Organism: Bifidobacterium longum subsp. longum strain JCM 11343

Toxin (Protein)

• Gene name: relE
• Uniprot ID: I3BGL7
• Locus tag: BL1343_RS10565
• Protein ID: WP_007056255.1
• Coordinates: 2469880..2470215 (-)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: I3BGP0
• Locus tag: BL1343_RS10570
• Protein ID: WP_007056990.1
• Coordinates: 2470219..2470488 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BL1343_RS10520	2464978..2465652	+	675	WP_077322431.1	YidC/Oxa1 family membrane protein insertase	-
BL1343_RS10525	2465754..2466374	+	621	WP_131269761.1	NUDIX hydrolase	-
BL1343_RS10530	2466403..2466726	+	324	WP_074709766.1	amidohydrolase	-
BL1343_RS10535	2466890..2467351	-	462	WP_019727563.1	HipA N-terminal domain-containing protein	-
BL1343_RS10540	2467375..2467668	-	294	WP_012471870.1	hypothetical protein	-
BL1343_RS10545	2467761..2468402	-	642	WP_007056262.1	hypothetical protein	-
BL1343_RS10550	2468616..2468795	+	180	WP_007056286.1	antitoxin VbhA family protein	-
BL1343_RS10555	2468792..2469376	+	585	WP_007056278.1	Fic family protein	-
BL1343_RS10560	2469579..2469863	-	285	WP_007056282.1	hypothetical protein	-
BL1343_RS10565	2469880..2470215	-	336	WP_007056255.1	type II toxin-antitoxin system YafQ family toxin	Toxin
BL1343_RS10570	2470219..2470488	-	270	WP_007056990.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BL1343_RS10575	2470673..2471841	-	1169	Protein_2041	ABC transporter permease	-
BL1343_RS10580	2471838..2472516	-	679	Protein_2042	ABC transporter ATP-binding protein	-
BL1343_RS10585	2472513..2473401	-	889	Protein_2043	hypothetical protein	-
BL1343_RS10590	2473398..2473912	-	515	Protein_2044	hypothetical protein	-
BL1343_RS10595	2474038..2474733	+	696	WP_003829410.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2450293..2485884	35591

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (3-87)

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 12650.60 Da
• Isoelectric Point: 9.1088

>T177336 WP_007056255.1 NZ_CP062940:c2470215-2469880 [Bifidobacterium longum subsp. longum]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELFGQIAGLHPALNQPTAI

Nucleotide

• Length: 336 bp

>T177336 NZ_CP083444:c1049681-1049358 [Bartonella taylorii]
ATGCGTGGTTCTCTCGTAACAATAGCTATACAAGGCGATTTTGGTAAACCAAGACCCGCATTGATCATTCAAGCTAATCA
ATTTAGTGAACATACCAGCATGACGGTTTTACCAATTACAAGTACACTTGTTGATGCGCCATTACTCCGTATTACTATCC
AACCAGACAGCAAAAATGGTTTACAAAAACCTTCGCAAGTGATGATTGATAAGATTATGACGGTAAGGTGTGAAAAAGTT
AGTCCAGCTTTCGGTTCCATTCGAGCAGACAAAATGTTAGAAATTGAACGCTGTCTGGCTGTATTTTTAGGAATAGTAAA
ATAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9844.16 Da
• Isoelectric Point: 4.5742

>AT177336 WP_007056990.1 NZ_CP062940:c2470488-2470219 [Bifidobacterium longum subsp. longum]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVREKRIPLNLSYTIVPPETMEALDEAKNRLADGQPRFNSA
DEMFDSLGI

Nucleotide

• Length: 270 bp

>AT177336 NZ_CP083444:c1049293-1048991 [Bartonella taylorii]
ATGTTTACAGTGTACAAAACAGAGTATTTTATAAAATGGCTAGATTCTTTAAAAGATGAGATTGCACAAGCACATATAGT
TAAACGAATTGCAAGAATAGAAACCGGATTTCTTGGTAATGTAAAATTCTTTCGTGGAATTGGAGAATTGAAAATATATC
ATGGACCAGGTTACAGAATCTATTTTGTAAAACAAGGTAAACAAATAATTTTATTATTAAATGCGGGTGATAAATCTACA
CAACAGAGGGATATCGAAAAAGCTCTTCGATTAGTAAAGGAAATGAAGCATGGAAATTACTAA

Structures

Toxin

• AlphaFold DB: I3BGL7

Antitoxin

• AlphaFold DB: I3BGP0