Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4376915..4377534 Replicon chromosome
Accession NZ_CP062916
Organism Raoultella terrigena strain Res13-Abat-PEB01-P1-04-A

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4Z516
Locus tag IMO34_RS20790 Protein ID WP_041144355.1
Coordinates 4377316..4377534 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8B4Z4D4
Locus tag IMO34_RS20785 Protein ID WP_041144356.1
Coordinates 4376915..4377289 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IMO34_RS20775 4372077..4373258 + 1182 WP_041144358.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IMO34_RS20780 4373293..4376439 + 3147 WP_041144357.1 multidrug efflux RND transporter permease subunit -
IMO34_RS20785 4376915..4377289 + 375 WP_041144356.1 Hha toxicity modulator TomB Antitoxin
IMO34_RS20790 4377316..4377534 + 219 WP_041144355.1 hemolysin expression modulator Hha Toxin
IMO34_RS20795 4377683..4378249 + 567 WP_195709751.1 maltose O-acetyltransferase -
IMO34_RS20800 4378348..4378815 + 468 WP_041144353.1 YlaC family protein -
IMO34_RS20805 4378787..4380244 - 1458 WP_123551010.1 PLP-dependent aminotransferase family protein -
IMO34_RS20810 4380346..4381056 + 711 WP_195709752.1 GNAT family N-acetyltransferase -
IMO34_RS20815 4381053..4381193 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
IMO34_RS20820 4381196..4381456 - 261 WP_041144350.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8580.94 Da        Isoelectric Point: 7.9907

>T177320 WP_041144355.1 NZ_CP062916:4377316-4377534 [Raoultella terrigena]
MSGEPLTKTDYLMRLRRCQTIDTLERVIEKNKYELPDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T177320 NZ_CP083443:346272-346640 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14397.16 Da        Isoelectric Point: 4.8886

>AT177320 WP_041144356.1 NZ_CP062916:4376915-4377289 [Raoultella terrigena]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIDHIATFALNYKIKYAEDNKLIAQLDEYL
DDTFMLFSSYGINSVDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT177320 NZ_CP083443:346054-346275 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4Z516

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4Z4D4

References