Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1848716..1849218 | Replicon | chromosome |
| Accession | NZ_CP062883 | ||
| Organism | Escherichia coli strain Res13-Lact-PEA06-10 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | IMP66_RS08740 | Protein ID | WP_000767829.1 |
| Coordinates | 1848964..1849218 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | IMP66_RS08735 | Protein ID | WP_001259255.1 |
| Coordinates | 1848716..1848967 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IMP66_RS08710 | 1843894..1844961 | - | 1068 | WP_029397756.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| IMP66_RS08715 | 1844961..1846031 | - | 1071 | WP_000108937.1 | histidinol-phosphate transaminase | - |
| IMP66_RS08720 | 1846028..1847332 | - | 1305 | WP_021545648.1 | histidinol dehydrogenase | - |
| IMP66_RS08725 | 1847338..1848237 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| IMP66_RS08730 | 1848383..1848433 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| IMP66_RS08735 | 1848716..1848967 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| IMP66_RS08740 | 1848964..1849218 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| IMP66_RS08745 | 1849301..1850125 | + | 825 | WP_000754758.1 | SDR family oxidoreductase | - |
| IMP66_RS08750 | 1850171..1851100 | + | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
| IMP66_RS08755 | 1851315..1851377 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| IMP66_RS08760 | 1851367..1852725 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| IMP66_RS08765 | 1852950..1853912 | + | 963 | WP_195686648.1 | IS5 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1852950..1853912 | 962 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T177118 WP_000767829.1 NZ_CP062883:1848964-1849218 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T177118 NZ_CP083174:1296794-1297582 [Gardnerella vaginalis]
ATGGTTATAGAAGATTTTAGCGAAGAGTATTTTACTCACTGTTTGTTAAGAAATTTACGTTCTTTACAAATGTATAAGCA
TGCAGATTTGCATCCTAAGGCGGTTTTACTCGGTGGTCAAAGTGGTGCTGGCAAAACGACCATTCATGTAATAAAACAAA
AAGAATTTAACGGTAACATAATAATCCTTGATGCTGATAGCTATAGGACTCAACACCCTTATTATTGCGAGTTGCTTGAT
AAATACGGTAAAGAAAGTGTTAAATATACGAGTGCTTTTTCAGCAAAAATGGTGAGAAGCTTAATTGATGAGTTAAGTTC
TAAAAAATATAATCTCATAATTGAAGGTACTTTGCGCAGTGTTGAAGTTCCTAGTAGTACTGCGAAAATGTTGATAGATC
GTGGTTACCGTATTTCTCTTGCTGTCATTGCAACAAAACCTGAATTGTCATGGATCAGTACGCTGATTCGCTACAGGGAA
ATGTATTTGGAAGATCCTAAAAGTGCTAGGGCAACTCCTAAGGATCATCACGACAATATTGTGAACAATATAGTAGATAA
CTTGTTGAAATTAGAACAATCGAAAATATTTGACAGAATTCAGATTTACAAGCGAGACGAAAAATGTATATATGATTCTG
ATTCGTATAAAAATAGTCCAAATATTACAGCAGCTAGTGTTCTTAAGGAAGTGCTCTTTGGCAAGAAAACTATTGATGAG
AAAAAGTTGATTTGCCACGCTAAGAATAGGTTGAATGAACTAGACAAGTTGATAGATAAAAGTTTGTAG
ATGGTTATAGAAGATTTTAGCGAAGAGTATTTTACTCACTGTTTGTTAAGAAATTTACGTTCTTTACAAATGTATAAGCA
TGCAGATTTGCATCCTAAGGCGGTTTTACTCGGTGGTCAAAGTGGTGCTGGCAAAACGACCATTCATGTAATAAAACAAA
AAGAATTTAACGGTAACATAATAATCCTTGATGCTGATAGCTATAGGACTCAACACCCTTATTATTGCGAGTTGCTTGAT
AAATACGGTAAAGAAAGTGTTAAATATACGAGTGCTTTTTCAGCAAAAATGGTGAGAAGCTTAATTGATGAGTTAAGTTC
TAAAAAATATAATCTCATAATTGAAGGTACTTTGCGCAGTGTTGAAGTTCCTAGTAGTACTGCGAAAATGTTGATAGATC
GTGGTTACCGTATTTCTCTTGCTGTCATTGCAACAAAACCTGAATTGTCATGGATCAGTACGCTGATTCGCTACAGGGAA
ATGTATTTGGAAGATCCTAAAAGTGCTAGGGCAACTCCTAAGGATCATCACGACAATATTGTGAACAATATAGTAGATAA
CTTGTTGAAATTAGAACAATCGAAAATATTTGACAGAATTCAGATTTACAAGCGAGACGAAAAATGTATATATGATTCTG
ATTCGTATAAAAATAGTCCAAATATTACAGCAGCTAGTGTTCTTAAGGAAGTGCTCTTTGGCAAGAAAACTATTGATGAG
AAAAAGTTGATTTGCCACGCTAAGAATAGGTTGAATGAACTAGACAAGTTGATAGATAAAAGTTTGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT177118 WP_001259255.1 NZ_CP062883:1848716-1848967 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT177118 NZ_CP083174:1296282-1296755 [Gardnerella vaginalis]
ATGGTTTCTGTGAATATTCGAGCACTACGTCGCTCAAAAAAAATAACTCAACAAGAGTTAGCTGAAGCATTAGGAGTATC
TCGTAATAGCATTGTGCGATACGAAAATGGTACAAGTGCTATTTCAACTAGGTTAATAGATAAGATTTGTGATAAATTCA
AGGTTTCTCTTTTTGATATCGTACATGAAAAAGAATTATCTGCATCTGATAAATACGATTTGAATATGAAGATTGAAGTT
TTAAAGGAGCGTGGCGCACTTTTACTGGCTCGTTTATATAAATACGAGGATAGTATGAATATACAATTTGATGATTCTTC
TAATGCATGGATTGCAATTAGTGATGATTTATCAGATGTAATTAATACAAAGATTTATACATCTACAAATTTTGAAGATA
TAAATCGTTATATCGGATATTTAGATGGCATAGAACGCTTGCTTGAATACGTAAGTTGCAATAAAAATAGTTAA
ATGGTTTCTGTGAATATTCGAGCACTACGTCGCTCAAAAAAAATAACTCAACAAGAGTTAGCTGAAGCATTAGGAGTATC
TCGTAATAGCATTGTGCGATACGAAAATGGTACAAGTGCTATTTCAACTAGGTTAATAGATAAGATTTGTGATAAATTCA
AGGTTTCTCTTTTTGATATCGTACATGAAAAAGAATTATCTGCATCTGATAAATACGATTTGAATATGAAGATTGAAGTT
TTAAAGGAGCGTGGCGCACTTTTACTGGCTCGTTTATATAAATACGAGGATAGTATGAATATACAATTTGATGATTCTTC
TAATGCATGGATTGCAATTAGTGATGATTTATCAGATGTAATTAATACAAAGATTTATACATCTACAAATTTTGAAGATA
TAAATCGTTATATCGGATATTTAGATGGCATAGAACGCTTGCTTGAATACGTAAGTTGCAATAAAAATAGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|