Detailed information of TA system TA176798

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 67754..68018
• Replicon: plasmid unnamed476
• Accession: NZ_CP062836
• Organism: Escherichia coli strain Res13-Lact-PER04-33

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Y6M3
• Locus tag: IMQ22_RS23800
• Protein ID: WP_001331364.1
• Coordinates: 67866..68018 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	67754..67811 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IMQ22_RS23785	62993..65284	-	2292	WP_001289276.1	hypothetical protein	-
IMQ22_RS23790	65277..66347	-	1071	WP_000151583.1	IncI1-type conjugal transfer protein TrbB	-
IMQ22_RS23795	66366..67574	-	1209	WP_000121273.1	IncI1-type conjugal transfer protein TrbA	-
-	67754..67811	-	58	NuclAT_0	-	Antitoxin
-	67754..67811	-	58	NuclAT_0	-	Antitoxin
-	67754..67811	-	58	NuclAT_0	-	Antitoxin
-	67754..67811	-	58	NuclAT_0	-	Antitoxin
IMQ22_RS23800	67866..68018	+	153	WP_001331364.1	Hok/Gef family protein	Toxin
IMQ22_RS23805	68090..68341	-	252	WP_001291964.1	hypothetical protein	-
IMQ22_RS23810	69000..69176	-	177	WP_001054904.1	hypothetical protein	-
IMQ22_RS23815	69568..69777	+	210	WP_000062603.1	HEAT repeat domain-containing protein	-
IMQ22_RS23820	69849..70499	-	651	WP_001178506.1	plasmid IncI1-type surface exclusion protein ExcA	-
IMQ22_RS23825	70573..72741	-	2169	WP_021537350.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	dfrA17 / aadA5 / sul2 / blaCTX-M-1	-	1..109656	109656

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5775.13 Da
• Isoelectric Point: 8.7948

>T176798 WP_001331364.1 NZ_CP062836:67866-68018 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T176798 NZ_CP082948:c1957699-1957370 [Streptococcus suis]
ATGGAATTTGAGTCTTATTCAGTGATACTTGCTCCAGCAGTGGAGAAGGAATTGGCAGTTATTTACGCCTATTTTTCGGA
ACAGTTCTCAGAAGAAATTGCCAAAAGACGAATTGGGATGATTGTCGAAGCATTAGAGAGTTTGCAAATTTTTCCTGAAC
GTGGTTTTAACGCCGATAACCGTTTTGGTAAGCAGATAGACCCGCCTCATCTAACCCGAGGCTATGTCGTTGGAAAAGAC
TACATCGCCCTCTATCGCGTAGTGAAAAATGAAGTTCGAGTTGGTCATCTTTTTGCGACCAAGAGTGATTATGTGAAGTT
GTTGAAGTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT176798 NZ_CP062836:c67811-67754 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A5W9M382

Antitoxin